3-[1]naphthyl-2-phenyl-propionic acid | 101893-99-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-[1]naphthyl-2-phenyl-propionic acid
• 英文别名: 3-[1]Naphthyl-2-phenyl-propionsaeure；3-Naphthalen-1-yl-2-phenylpropanoic acid
• CAS: 101893-99-6
• 化学式: C₁₉H₁₆O₂
• 分子量: 276.335
• InChiKey: ZMOGIZHWBARKJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 3-[1]naphthyl-2-phenyl-propionic acid
  参考文献：
  名称：

  Reduction and Benzylation by Means of Benzyl Alcohol. V. A New Synthesis of α,β-Diarylpropionic Acids and the Corresponding Nitriles¹

  摘要：

  DOI：

  10.1021/ja01535a059

文献信息

• Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：US20020062033A1

  公开（公告）日：2002-05-23

  A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R 1 represents a protective group for a nitrogen atom; R 2 represents a methanesulfonyl group or p-toluenesulfonyl group; R 3 represents a hydrogen atom, an aralkyl group, or an alkyl group having 1 to 6 carbon atoms; and X represents a halogen atom. 1 The above process is useful as an industrial process for preparing intermediates of anticoagulant aromatic amidine derivatives described in Japanese Patent Application Laid-Open (kokai) No. 208946/1993.

  以下反应方程式中，制备由通式（5）和（6）表示的化合物或其盐的过程，其中R1代表氮原子的保护基；R2代表甲磺酰基或对甲苯磺酰基；R3代表氢原子、芳基烷基或具有1至6个碳原子的烷基；X代表卤素原子。该过程可用作制备抗凝药芳香酰胺衍生物中间体的工业过程，该中间体在日本专利申请公开（kokai）号208946/1993中有描述。
• 2-Phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0179487A1

  公开（公告）日：1986-04-30

  2-Phenylpropionic acid ester of Formula (l): wherein R represents p-nitrophenyl group, β-naphthyl group or 2-(β-naphthyl)ethyl group. Optical resolution of the above is carried out by preferential crystallization by seeding either one of the optical isomers into a super-saturated solution of a racemic modification thereof or a mixture of the optical isomers thereof. The efficiency of the optical resolution can be increased by optional addition of a racemizing agent comprising a strongly basic amine or an alcoholate.

  式（l）的 2-苯基丙酸酯： 其中 R 代表对硝基苯基、β-萘基或 2-（β-萘基）乙基。 上述物质的光学分辨是通过将其中一种光学异构体加入其外消旋体或其光学异构体混合物的过饱和溶液中进行优先结晶来实现的。可选择添加由强碱性胺或醇酸酯组成的消旋化剂，从而提高光学解析的效率。
• PROCESS FOR PREPARING 2-PHENYL-3-NAPHTHYLPROPIONIC ACID DERIVATIVES
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0936215A1

  公开（公告）日：1999-08-18

  A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1 represents a protective groupfor a nitrogen atom; R2 represents a methanesulfonyl group or p-toluenesulfonyl group; R3 represents a hydrogen atom, an aralkyl group, or an alkyl group having 1 to 6 carbon atoms; and X represents a halogen atom. The above process is useful as an industrial process for preparing intermediates of anticoagulant aromatic amidine derivatives described in Japanese Patent Application Laid-Open (kokai) No. 208946/1993.

  一种制备下述反应方案中通式(5)和(6)所代表的化合物或其盐的工艺，其中 R1 代表氮原子的保护基团；R2 代表甲磺酰基或对甲苯磺酰基；R3 代表氢原子、芳烷基或具有 1 至 6 个碳原子的烷基；以及 X 代表卤素原子。 上述工艺可作为制备日本专利申请公开（kokai）第 208946/1993 号所述抗凝剂芳香族脒衍生物中间体的工业工艺。
• US4709082A
  申请人：——

  公开号：US4709082A

  公开（公告）日：1987-11-24
• US6252088B1
  申请人：——

  公开号：US6252088B1

  公开（公告）日：2001-06-26