2-Benzyl-4-(4-chloro-phenyl)-1,2,3,4-tetrahydro-isoquinolin-4-ol; hydrochloride | 142818-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-Benzyl-4-(4-chloro-phenyl)-1,2,3,4-tetrahydro-isoquinolin-4-ol; hydrochloride
• CAS: 142818-20-0
• 化学式: C₂₂H₂₀ClNO*ClH
• 分子量: 386.321
• InChiKey: WITLEQBBQKWUCS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-Benzyl-4-(4-chloro-phenyl)-1,2,3,4-tetrahydro-isoquinolin-4-ol; hydrochloride 在 三氯化铝 作用下， 以 苯 为溶剂， 反应 0.5h， 以82%的产率得到12-(4-Chloro-phenyl)-7,12-dihydro-5H-6,12-methano-dibenzo[c,f]azocine
  参考文献：
  名称：

  A New Synthesis of 7,12-Dihydro-12-phenyl-5H-6,12-methanodibenz[c,f]azocines via N-Benzyl-1,2,3,4-tetrahydro-4-phenylisoquinolin-4-ols

  摘要：

  7,12-Dihydro-12-phenyl-5H-6,12-methanodibenz[c,f]azocine derivatives were prepared from N-benzyl-1,2,3,4-tetrahydro-4-phenylisoquinolin-4-ols by an intramolecular Friedel-Crafts reaction.

  DOI：

  10.3987/com-91-5956

文献信息

• New Reduction Reaction of Benzylic Alcohols with Acid and Proof of the Intermolecular Hydride Shift Mechanism
  作者：Masaru Kihara、Jun-ichi Andoh、Chiaki Yoshida

  DOI：10.3987/com-99-8786

  日期：——

  The new reduction reaction of the hydroxy groups of 4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinolines (1) to the corresponding alkanes (2) with mineral and Lewis acids is reported. A stereoselective intermolecular hydride shift mechanism of the reduction was proved by reaction of the deuterated derivateives (14 and 15) of 1a with 10N HCl-C2H5OH and BBr3 in CH3CN.