N,N'-((1R,1'R,2R,2'R)-(ethane-1,2-diylbis(azanediyl))bis(1,2-diphenylethane-2,1-diyl))bis(4-methylbenzenesulfonamide) | 1119898-33-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N,N'-((1R,1'R,2R,2'R)-(ethane-1,2-diylbis(azanediyl))bis(1,2-diphenylethane-2,1-diyl))bis(4-methylbenzenesulfonamide)
• CAS: 1119898-33-7
• 化学式: C₄₄H₄₆N₄O₄S₂
• 分子量: 759.006
• InChiKey: CYRSMIDNWWNADM-OWIHLRRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  54.0
• 可旋转键数：
  17.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  116.4
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  1,2-二溴乙烷 、 (1R,2R)-(-)-N-(对甲基苯磺酰基)-1,2-二苯基乙二胺 以46%的产率得到N,N'-((1R,1'R,2R,2'R)-(ethane-1,2-diylbis(azanediyl))bis(1,2-diphenylethane-2,1-diyl))bis(4-methylbenzenesulfonamide)
  参考文献：
  名称：

  Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl-N’-tosyl-1,2-ethanediamine ligands

  摘要：

  The combination of an enantiomerically pure N'-alkylated derivative of N-4-toluenesulfonyl-1,2-diphenylethane-1,2-diamine (TsDPEN) with iridium trichloride results in the formation of a catalyst with high selectivity for ketone hydrogenation. Products with enantiomeric excesses of up to 84% were formed. The best results were obtained using a ligand with an n-alkyl chain and ortho-substituted acetophenone derivatives and other hindered derivatives. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.101