5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]imidazolidine-2,4-dione | 349636-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]imidazolidine-2,4-dione
• 英文别名: (4Z)-2-amino-4-[[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl]methylidene]-1H-imidazol-5-one
• CAS: 349636-50-6
• 化学式: C₁₇H₂₀N₄O₃
• 分子量: 328.371
• InChiKey: WTYOTHLIEHRAAS-KAMYIIQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  89.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]imidazolidine-2,4-dione 在 盐酸 作用下， 反应 4.0h， 以76%的产率得到5-[4-(4-oxopiperidin-1-yl)benzylidene]imidazolidine-2,4-dione
  参考文献：
  名称：

  Synthesis of Heterocycle Substituted 1-Aryl-4-piperidones

  摘要：

  A series of heterocycle substituted 1-aryl-4-piperidones were prepared via Knoevenagel condensations between nitrogen-containing 5-membered heterocycles and benzaldehyde (1) followed by reduction or amination. The oxadiazolidinedione ring was formed by reacting the N-hydroxyurea (10) with methyl chloroformate and sodium hydride.

  DOI：

  10.3987/com-02-9447
• 作为产物：
  描述：

  4-(1,4-二氧杂-8-氮杂螺[4.5]癸-8-基)苯甲醛 、 2-氨基-3,5-二氢-4H-咪唑-4-酮 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以90%的产率得到5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]imidazolidine-2,4-dione
  参考文献：
  名称：

  Synthesis of Heterocycle Substituted 1-Aryl-4-piperidones

  摘要：

  A series of heterocycle substituted 1-aryl-4-piperidones were prepared via Knoevenagel condensations between nitrogen-containing 5-membered heterocycles and benzaldehyde (1) followed by reduction or amination. The oxadiazolidinedione ring was formed by reacting the N-hydroxyurea (10) with methyl chloroformate and sodium hydride.

  DOI：

  10.3987/com-02-9447

文献信息

• Synthesis of Heterocycle Substituted 1-Aryl-4-piperidones
  作者：Baihua Hu、Michael Malamas、John Ellingboe

  DOI：10.3987/com-02-9447

  日期：——

  A series of heterocycle substituted 1-aryl-4-piperidones were prepared via Knoevenagel condensations between nitrogen-containing 5-membered heterocycles and benzaldehyde (1) followed by reduction or amination. The oxadiazolidinedione ring was formed by reacting the N-hydroxyurea (10) with methyl chloroformate and sodium hydride.