2-[8-methyl-1-(oxan-4-yl)-4-oxo-5H-imidazo[1,5-a]quinoxaline-7-carbonyl]-3,4-dihydro-1H-isoquinoline-7-carbonitrile | 1243155-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-[8-methyl-1-(oxan-4-yl)-4-oxo-5H-imidazo[1,5-a]quinoxaline-7-carbonyl]-3,4-dihydro-1H-isoquinoline-7-carbonitrile
• CAS: 1243155-69-2
• 化学式: C₂₇H₂₅N₅O₃
• 分子量: 467.527
• InChiKey: OMQWJRAVSYTVPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• QUINOXALINE COMPOUND
  申请人：Kaizawa Hiroyuki

  公开号：US20110319385A1

  公开（公告）日：2011-12-29

  [Problem] Provided is a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like. [Means for Solution] The present inventors have investigated a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like, and thus, have found that an imidazoquinoxaline compound or a triazoloquinoxaline compound has a PDE9-inhibiting action, thereby completing the present invention. The imidazoquinoxaline compound or the triazoloquinoxaline compound of the present invention has a PDE9-inhibiting action and can be used as an agent for preventing and/or treating storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.

  提供一种具有PDE9抑制作用的化合物，可用作治疗和/或预防储存功能障碍、排尿功能障碍、膀胱/尿道疾病等药剂的活性成分。现有发明人研究了一种具有PDE9抑制作用的化合物，可用作治疗和/或预防储存功能障碍、排尿功能障碍、膀胱/尿道疾病等药剂的活性成分，因此，发现咪唑喹喔啉化合物或三唑喹喔啉化合物具有PDE9抑制作用，从而完成了本发明。本发明的咪唑喹喔啉化合物或三唑喹喔啉化合物具有PDE9抑制作用，可用作预防和/或治疗储存功能障碍、排尿功能障碍、膀胱/尿道疾病等药剂。
• US8357688B2
  申请人：——

  公开号：US8357688B2

  公开（公告）日：2013-01-22