Fubimina | 1984789-90-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Fubimina
• 英文别名: [1-(5-fluoropentyl)benzimidazol-2-yl]-naphthalen-1-ylmethanone
• CAS: 1984789-90-3
• 化学式: C₂₃H₂₁FN₂O
• 分子量: 360.4
• InChiKey: KUESSZMROAFKQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CANNABINOIDS AND DERIVATIVES FOR PROMOTING IMMUNOGENICITY OF TUMOR AND INFECTED CELLS
  申请人：Pascal Biosciences Inc.

  公开号：EP3743061A1

  公开（公告）日：2020-12-02
• [EN] CANNABINOIDS AND DERIVATIVES FOR PROMOTING IMMUNOGENICITY OF TUMOR AND INFECTED CELLS<br/>[FR] CANNABINOÏDES ET LEURS DÉRIVÉS POUR FAVORISER L'IMMUNOGÉNICITÉ DES CELLULES TUMORALES ET INFECTÉES
  申请人：PASCAL BIOSCIENCES INC

  公开号：WO2019144126A1

  公开（公告）日：2019-07-25

  This invention provides processes and compositions for enhancing the immunogenicity of tumor or infected cells by increasing expression of major histocompatibility complex (MHC) class I surface molecules. Tumor cells often circumvent immune recognition by reducing or eliminating MHC expression. The lack of MHC on their surface allows tumor cells to evade immune detection and enables uncontrolled growth. Similarly, certain viral or microbial infections result in MHC class I downregulation and the resulting immune evasion. With a unique reporter assay, we have determined that some cannabinoid compounds and structural analogs can increase MHC class I expression on tumor cells grown in cell culture. The increase of tumor and infected cell MHC class I expression will enable detection and destruction by cytotoxic T-lymphocyte cells. The process and compositions increase the immunogenicity of the target cells, e.g. tumor or infected cells, to enhance their destruction by cytotoxic lymphocytes. When administered in combination, such compositions may enhance the activity of immune- oncology and anti-infectious disease agents.