N-ethyl-5-methoxy-N-(thiophen-2-ylmethyl)benzofuran-2-carboxamide | 1374763-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-ethyl-5-methoxy-N-(thiophen-2-ylmethyl)benzofuran-2-carboxamide
• 英文别名: N-ethyl-5-methoxy-N-(thiophen-2-ylmethyl)-1-benzofuran-2-carboxamide
• CAS: 1374763-16-2
• 化学式: C₁₇H₁₇NO₃S
• 分子量: 315.393
• InChiKey: JPPIRCIBYYOVRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  70.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Priest Chad

  公开号：US20130324557A1

  公开（公告）日：2013-12-05

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

  本发明包括作为TRPM8调节剂有用的化合物，例如公式（I）的化合物及其亚属和种类；含有这些化合物的个人产品；以及这些化合物和个人产品的使用，特别是增加或诱导化学感受，例如冷却或寒冷感受的使用。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10016418B2

  公开（公告）日：2018-07-10

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

  本发明包括可用作 TRPM8 调节剂的化合物，如式（I）化合物及其亚属和种化合物；含有这些化合物的个人用品；以及这些化合物和个人用品的用途，特别是增加或诱导化学麻醉感觉的用途，如冷却或冷感。
• Cooling preparations
  申请人：Symrise AG

  公开号：US10182584B2

  公开（公告）日：2019-01-22

  Proposed are preparations, comprising special amides and menthol or menthol compounds or aromatic substances, characterized in that they have improved flavor and scent properties, and also that they allow the production of preparations, particularly emulsions with improved shelf life.

  建议的制剂由特殊酰胺和薄荷醇或薄荷醇化合物或芳香物质组成，其特点是它们具有更好的风味和香味特性，还能生产出保质期更长的制剂，特别是乳剂。
• [EN] COMPOUNDS USEFUL AS MODULATORS OF TRPM8<br/>[FR] COMPOSÉS UTILES EN TANT QUE MODULATEURS DE TRPM8
  申请人：SENOMYX INC

  公开号：WO2012061698A9

  公开（公告）日：2013-01-10
• PREPARATIONS
  申请人：SYMRISE AG

  公开号：US20150313820A1

  公开（公告）日：2015-11-05

  Proposed are preparations, comprising special amides and menthol or menthol compounds or aromatic substances, characterized in that they have improved flavor and scent properties, and also that they allow the production of preparations, particularly emulsions with improved shelf life.