cis-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-2-(hydroxyacetyl)-5H-<1>benzopyrano<4,3-c>piperidine | 83732-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: cis-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-2-(hydroxyacetyl)-5H-<1>benzopyrano<4,3-c>piperidine
• CAS: 83732-28-9
• 化学式: C₂₅H₃₉NO₄
• 分子量: 417.589
• InChiKey: LOLVHYOCRQVNRM-TZJYRCSTSA-N

反应信息

• 作为产物：
  描述：

  在 氢氧化钾 作用下， 反应 2.0h， 生成 cis-5,5-dimethyl-8-(1,2-dimethylheptyl)-10-hydroxy-2-(hydroxyacetyl)-5H-<1>benzopyrano<4,3-c>piperidine
  参考文献：
  名称：

  New antihypertensive cannabinoids

  摘要：

  A number of azacannabinoids containing hydroxyacyl and aminoacetyl substituents on the nitrogen atom were synthesized. The hydroxyacetyl and gamma-hydroxybutyryl derivatives were potent antihypertensive agents (minimum effective dose, 3-5 mg/kg, orally) of the same order of activity as the highly CNS-active N-propargyl derivatives Ia and Ib. Furthermore, 4a showed weak stimulant properties at hypotensive dose levels, in contrast to the strongly CNS-depressant action characteristic of the N-propargyl analogues.

  DOI：

  10.1021/jm00356a017