Zybrestat

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Zybrestat
• 英文别名: disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
• 化学式: C18H19Na2O8P
• 分子量: 440.3
• InChiKey: VXNQMUVMEIGUJW-XNOMRPDFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.89
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME
  申请人：Popov Andrei

  公开号：US20130096083A1

  公开（公告）日：2013-04-18

  The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer.

  使用异喹啉类化合物制备药物，包括新型异喹啉类化合物及其合成方法。特别是用于治疗病理性血管生成的异喹啉类衍生物，尤其是用于治疗癌症。
• Diphenylethylene compounds and uses thereof
  申请人：Muller W. George

  公开号：US20050107339A1

  公开（公告）日：2005-05-19

  The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

  本发明涉及二苯乙烯化合物和包含二苯乙烯化合物的组合物。本发明还涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗各种疾病和紊乱的方法。具体而言，该发明涉及通过向需要的受试者施用一种或多种二苯乙烯化合物来预防或治疗癌症或炎症性紊乱的方法。本发明还涉及包含一种或多种二苯乙烯化合物的制品和工具包。
• [EN] TREATMENT OF MACULAR DEGENERATION<br/>[FR] TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE
  申请人：BIONOMICS LTD

  公开号：WO2011022781A1

  公开（公告）日：2011-03-03

  The present invention relates generally to methods for treating macular degeneration, and in particular age-related macular degeneration, involving the use of specific benzofuran based compounds.

  本发明涉及治疗黄斑变性的方法，特别是涉及使用特定苯并呋喃化合物治疗老年性黄斑变性。
• Substituted heterocyclic compounds and uses thereof
  申请人：Muller W. George

  公开号：US20060052596A1

  公开（公告）日：2006-03-09

  The present invention relates to substituted heterocyclic compounds and compositions comprising a substituted heterocyclic compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more substituted heterocyclic compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more substituted heterocyclic compounds. The present invention further relates to articles of manufacture and kits comprising one or more substituted heterocyclic compounds.

  本发明涉及取代杂环化合物和包含取代杂环化合物的组合物。本发明还涉及通过向需要的受试者施用一种或多种取代杂环化合物来预防或治疗各种疾病和紊乱的方法。具体来说，本发明涉及通过向需要的受试者施用一种或多种取代杂环化合物来预防或治疗癌症或炎症性紊乱的方法。本发明还涉及包含一种或多种取代杂环化合物的制品和试剂盒。
• Tubulin binding agents and corresponding prodrug constructs
  申请人：——

  公开号：US20040043969A1

  公开（公告）日：2004-03-04

  A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.

  发现了一系列多样化的微管蛋白结合剂，这些剂在一般意义上结构特征为半刚性的分子框架，能够保持适当的芳基-芳基，伪π堆积距离以进行微管蛋白的分子识别。在酚或氨基形式下，这些配体可以进一步功能化以制备磷酸酯、磷酸盐、磷酰胺和其他前药，能够表现出选择性靶向和破坏肿瘤细胞血管的能力。