(6S,7R,8R,9S)-6-(3-chroman-6-ylmethyl-4-ethyl-phenyl)-2,5-dioxa-spiro[3.5]nonane-7,8,9-triol | 1290630-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (6S,7R,8R,9S)-6-(3-chroman-6-ylmethyl-4-ethyl-phenyl)-2,5-dioxa-spiro[3.5]nonane-7,8,9-triol
• 英文别名: (6S,7R,8R,9S)-6-(3-chroman-6-ylmethyl-4-ethyl-phenyl)-2,6-dioxa-spiro[3.5]nonane-7,8,9-triol；(6S,7R,8R,9S)-6-[3-(3,4-dihydro-2H-chromen-6-ylmethyl)-4-ethylphenyl]-2,5-dioxaspiro[3.5]nonane-7,8,9-triol
• CAS: 1290630-17-9
• 化学式: C₂₅H₃₀O₆
• 分子量: 426.51
• InChiKey: KTMBCNICLJFRNS-LWSSLDFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  88.4
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• GLYCOSIDE DERIVATIVE AND USES THEREOF
  申请人：Bebernitz Gregory Raymond

  公开号：US20120196813A1

  公开（公告）日：2012-08-02

  This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

  本发明涉及由以下公式（I）表示的化合物： 其中变量如上所定义，这些化合物可用于治疗由钠D-葡萄糖共转运蛋白（SGLT）介导的疾病和症状，例如糖尿病。该发明还提供了治疗这些疾病和症状的方法，以及用于治疗的组合物等。
• US8394772B2
  申请人：——

  公开号：US8394772B2

  公开（公告）日：2013-03-12
• [EN] GLYCOSIDE DERIVATIVE AND USES THEREOF<br/>[FR] DÉRIVÉ DE GLYCOSIDE ET SES UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2011048148A2

  公开（公告）日：2011-04-28

  This invention relates to compounds represented by formula (I) wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.