6-Mercapto-7-methoxy-chroman-2-yl-acetic acid methyl ester | 600167-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-Mercapto-7-methoxy-chroman-2-yl-acetic acid methyl ester
• 英文别名: methyl 2-(7-methoxy-6-sulfanyl-3,4-dihydro-2H-chromen-2-yl)acetate
• CAS: 600167-24-6
• 化学式: C₁₃H₁₆O₄S
• 分子量: 268.334
• InChiKey: FLNRWFJVHDQVPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-Mercapto-7-methoxy-chroman-2-ol 、 methyl-triphenyphosphoranylidene-acetate 生成 6-Mercapto-7-methoxy-chroman-2-yl-acetic acid methyl ester
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Compounds that modulate PPAR activity and methods of preparation
  申请人：——

  公开号：US20030207915A1

  公开（公告）日：2003-11-06

  This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.

  这项发明揭示了能够改变PPAR活性的化合物。该发明还揭示了这些化合物的药用盐、包含这些化合物或其盐的药用组合物，以及将它们用作治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。本发明还揭示了制备所述化合物的方法。
• SUBSTITUTED THIAZOLES AND OXAZOLES THAT MODULATE PPAR ACTIVITY
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1480641A1

  公开（公告）日：2004-12-01
• US6867224B2
  申请人：——

  公开号：US6867224B2

  公开（公告）日：2005-03-15
• US7109222B2
  申请人：——

  公开号：US7109222B2

  公开（公告）日：2006-09-19
• [EN] SUBSTITUTED THIAZOLES AND OXAZOLES THAT MODULATE PPAR ACTIVITY<br/>[FR] THIAZOLES ET OXAZOLES SUBSTITUES MODULANT L'ACTIVITE DE PPAR
  申请人：WARNER LAMBERT CO

  公开号：WO2003074051A1

  公开（公告）日：2003-09-12

  This invention discloses compounds of structures (1) and (2) that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.