2-ethyl-6-phenylnaphthalene | 1016160-95-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-ethyl-6-phenylnaphthalene
• 英文别名: 2-Phenyl-6-ethylnaphthalene
• CAS: 1016160-95-4
• 化学式: C₁₈H₁₆
• 分子量: 232.325
• InChiKey: ANWXWEWQYYXCQF-UHFFFAOYSA-N

物化性质

• 沸点：
  378.0±17.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  6-乙基-2-甲氧基萘 、 phenylmagnesium bromide 在 三环己基膦 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 10.0h， 以74%的产率得到2-ethyl-6-phenylnaphthalene
  参考文献：
  名称：

  Direct Benzylic Alkylation via Ni-Catalyzed Selective Benzylic sp³ C−O Activation

  摘要：

  This article demonstrates the first cross coupling of benzyl ether with Grignard reagents via Ni-catalyzed benzylic sp(3) C-O activation with high efficiency and excellent chemoselectivity. Benzylic sp(3) C-O and aryl sp(2) C-O were differentiated, controlled by ligands.

  DOI：

  10.1021/ja710944j

文献信息

• An Improvement of Nickel Catalyst for Cross-coupling Reaction of Arylboronic Acids with Aryl Carbonates by Using a Ferrocenyl Bisphosphine Ligand
  作者：Ryoichi Kuwano、Ryosuke Shimizu

  DOI：10.1246/cl.2011.913

  日期：2011.9.5

  Aryl carbonates work as electrophilic substrates for the Suzuki–Miyaura reaction in the presence of the nickel catalyst, which is generated from [Ni(cod)2] and ferrocenyl bisphosphine, DCyPF. The nickel catalyst allowed the cross-coupling reaction of arylboronic acids with non-benzo-fused aryl carbonates as well as naphthyl substrates.

  芳基碳酸酯在镍催化剂存在下，作为铃木–宫浦反应的电亲体底物，该催化剂由[Ni(cod)2]和铁烯基双磷酸酯DCyPF生成。镍催化剂促进了芳基硼酸与非苯并融合的芳基碳酸酯以及萘基底物的交叉偶联反应。
• Direct Benzylic Alkylation via Ni-Catalyzed Selective Benzylic sp³ C−O Activation
  作者：Bing-Tao Guan、Shi-Kai Xiang、Bi-Qin Wang、Zuo-Peng Sun、Yang Wang、Ke-Qing Zhao、Zhang-Jie Shi

  DOI：10.1021/ja710944j

  日期：2008.3.1

  This article demonstrates the first cross coupling of benzyl ether with Grignard reagents via Ni-catalyzed benzylic sp(3) C-O activation with high efficiency and excellent chemoselectivity. Benzylic sp(3) C-O and aryl sp(2) C-O were differentiated, controlled by ligands.