2,2,3,3-Tetramethyl-1,4-benzodioxine | 75768-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2,2,3,3-Tetramethyl-1,4-benzodioxine
• CAS: 75768-16-0
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: JVYJQWXTQNHBMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  频哪醇 、 1,2-环己二酮 在 二(氰基苯)二氯化钯 作用下， 以 苯 为溶剂， 以52%的产率得到2,2,3,3-Tetramethyl-1,4-benzodioxine
  参考文献：
  名称：

  One-step synthesis of 1,4-benzodioxanes by reaction of 1,2-cyclohexanedione with vicinal diols promoted by dichlorobis(benzonitrile)palladium(II)

  摘要：

  DOI：

  10.1021/jo00318a031

文献信息

• COMPOSITIONS CONTAINING O-SULFATE AND O-PHOSPHATE CONTAINING ARYL SULFONAMIDE DERIVATIVES USEFUL AS beta-AMYLOID INHIBITORS
  申请人：LI David Zenan

  公开号：US20090181932A1

  公开（公告）日：2009-07-16

  A synthetic compound characterized by having the structure of formula I or II or a pharmaceutically acceptable salt and/or hydrate thereof is provided. Formula I and formula II are defined as follows. wherein R 1 is substituted aryl or substituted heteroaryl; R 2 and R 3 are independently selected from the group consisting of CF 3 , substituted phenyl, C 1 -C 4 alkyl, substituted C 1 -C 4 alkyl, (CF 3 ) n C 1 -C 4 alkyl, (CF 3 ) n (substituted C 1 -C 4 alkyl), provided that when R 2 or R 3 is CF 3 , the other is not an unsubstituted alkyl; R 4 and R 4′ are independently selected from the group consisting of M, C 1 -C 4 alkyl, phenyl, and benzyl, wherein M is a metal ion is selected from the group consisting of sodium, lithium, calcium, magnesium and potassium, or R 4 and R 4′ are taken together to form a cyclic structure. Methods of making such compounds and uses thereof are also provided.

  提供一种具有I或II式结构或其药学上可接受的盐和/或水合物的合成化合物。其中，公式I和公式II定义如下：其中R1为取代芳基或取代杂环芳基；R2和R3分别选自CF3、取代苯基、C1-C4烷基、取代C1-C4烷基、(CF3)nC1-C4烷基、(CF3)n(取代C1-C4烷基)的群，但当R2或R3为CF3时，另一个不是未取代的烷基；R4和R4′分别选自M、C1-C4烷基、苯基和苄基的群，其中M是选择自钠、锂、钙、镁和钾的金属离子，或R4和R4′结合形成环状结构。还提供制备这种化合物的方法和其用途。
• GLYCOSIDASE INHIBITORS
  申请人：Asceneuron SA

  公开号：US20170298082A1

  公开（公告）日：2017-10-19

  The disclosure relates to compounds of formula (I) useful in the treatment of tauopathies and Alzheimer's disease wherein A, R, W, Q, n, and m are described herein.
• PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
  申请人：Jiangsu Hengrui Medicine Co., Ltd.

  公开号：US20180170943A1

  公开（公告）日：2018-06-21

  The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention relates to the piperidine derivative as shown by general formula (I) and the preparation method thereof and a pharmaceutical composition containing the same, and the use thereof as an estrogen receptor modulator in the treatment of estrogen receptor mediated or dependent diseases or conditions, the diseases preferably being breast cancer. In the abstract, the definition of each substituent of the general formula (I) is the same as that in the description.
• One-step synthesis of 1,4-benzodioxanes by reaction of 1,2-cyclohexanedione with vicinal diols promoted by dichlorobis(benzonitrile)palladium(II)
  作者：Enrico Mincione、Antonio Sirna、Daniele Covini

  DOI：10.1021/jo00318a031

  日期：1981.2