N-(1-methyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)cyclopentanesulfonamide | 1415927-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: N-(1-methyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)cyclopentanesulfonamide
• 英文别名: N-[1-methyl-3-(1-methyl-2,3-dihydroindol-6-yl)pyrrolo[2,3-b]pyridin-4-yl]cyclopentanesulfonamide
• CAS: 1415927-18-2
• 化学式: C₂₂H₂₆N₄O₂S
• 分子量: 410.54
• InChiKey: AMQIBUZGJLKWNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：GLAXO WELLCOME MFG PTE LTD

  公开号：WO2012170752A1

  公开（公告）日：2012-12-13

  The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.

  本发明涉及新型NADPH氧化酶II抑制剂及其在治疗由NADPH氧化酶酶介导的疾病中的应用。
• NOVEL COMPOUNDS
  申请人：Chen Deborah W.

  公开号：US20140155375A1

  公开（公告）日：2014-06-05

  The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.

  本发明涉及新型NADPH氧化酶II抑制剂及其在治疗由NADPH氧化酶酶介导的疾病中的应用。
• US8877742B2
  申请人：——

  公开号：US8877742B2

  公开（公告）日：2014-11-04
• [EN] FORMULATIONS OF (R)-1-(2,2-DIFLUROBENZO[D][1,3] DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYL PROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE<br/>[FR] PRÉPARATIONS DE (R)-1-(2,2-DIFLUROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-MÉTHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE
  申请人：VERTEX PHARMA

  公开号：WO2012170061A1

  公开（公告）日：2012-12-13

  The present invention relates to formulations of (R)-l-(2,2- difluorobenzo[d][l,3]dioxol-5-yl)-N-(l-(2,3-dihydroxypropyl)-6-fluoro-2-(l-hydroxy-2- methylpropan-2-yl)-lH-indol-5-yl)cyclopropanecarboxamide (Compound 1), pharmaceutical packs or kits thereof, and methods of treatment therewith.