8-[(5-fluoro-3,4-dihydro-2H-chromen-4-yl)amino]-N,N,2-trimethylimidazo[1,2-a]pyridine-6-carboxamide | 950596-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-[(5-fluoro-3,4-dihydro-2H-chromen-4-yl)amino]-N,N,2-trimethylimidazo[1,2-a]pyridine-6-carboxamide
• CAS: 950596-07-3
• 化学式: C₂₀H₂₁FN₄O₂
• 分子量: 368.411
• InChiKey: KALOSIFBXVGRFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Chromane Derivatives
  申请人：Matsumoto Yukari

  公开号：US20070219237A1

  公开（公告）日：2007-09-20

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：R1、R2、R3、R4、R5、R6、R7、R8A和B分别如本文所述或其药学上可接受的盐，以及含有这种化合物的组合物和治疗方法和使用，包括这种化合物用于治疗由酸泵拮抗活性介导的疾病，例如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、喉咽反流病、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID引起的溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃利森综合征、非侵蚀性反流病（NERD）、内脏疼痛、癌症、心灼热、恶心、食管炎、吞咽困难、多口水、气道疾病或哮喘。