2-Isopropyl-2,5,7,8-tetramethyl-chroman-6-ol | 26091-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-Isopropyl-2,5,7,8-tetramethyl-chroman-6-ol
• 英文别名: 2,5,7,8-Tetramethyl-2-propan-2-yl-3,4-dihydrochromen-6-ol
• CAS: 26091-41-8
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: ZEAXDRATMRUDIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Treating Arrhythmia with Mitochondrial-Targeted Antioxidants
  申请人：Rhode Island Hospital

  公开号：US20170189429A1

  公开（公告）日：2017-07-06

  This invention relates to reducing the risk of arrhythmias as a result of an acute cardiovascular disorder or injury such as a myocardial infarction by using mitochondrial-targeted antioxidants to improve cardiac function.
• PHOSPHONIUM-BASED IONIC DRUG CONJUGATES
  申请人：Anthos Partners, LP

  公开号：US20200353087A1

  公开（公告）日：2020-11-12

  Phosphonium-based ionic conjugates (PBICs) are described. The PBICs each include a cationic binding partner comprising a phosphonium ion and an anionic binding partner comprising a pharmaceutically active compound, or prodrug, or derivative thereof. The conjugate can have at least one enhanced physiochemical, pharmacokinetic and/or therapeutic quality as compared to the pharmaceutically active compound when not provided in a PBIC. The phosphonium-containing cationic binding partner can also serve to enhance delivery of the anionic binding partner to the cytosol and/or the inner mitochondrial space. Methods of preparing the PBICs and using the PBICs to treat disease are also described.