N,N-dibenzoyl-5'-O-mesyl-2'-deoxyadenosine | 556826-37-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N,N-dibenzoyl-5'-O-mesyl-2'-deoxyadenosine
• CAS: 556826-37-0
• 化学式: C₂₅H₂₃N₅O₇S
• 分子量: 537.553
• InChiKey: KSIIPPIZPDPRGA-XUVXKRRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.94
• 重原子数：
  38.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  153.81
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  N,N-dibenzoyl-5'-O-mesyl-2'-deoxyadenosine 在 palladium on activated charcoal 叠氮化锂 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 N-[9-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxyoxolan-2-yl]purin-6-yl]benzamide
  参考文献：
  名称：

  Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences

  摘要：

  Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3'-->5' direction and involves coupling of 3'-Fmoc protected thiourea in the presence of HgCl2/TEA with the corresponding 5'-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00119-7
• 作为产物：
  描述：

  2'-脱氧腺苷 在 吡啶 、 三甲基氯硅烷 作用下， 反应 12.5h， 生成 N,N-dibenzoyl-5'-O-mesyl-2'-deoxyadenosine
  参考文献：
  名称：

  Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences

  摘要：

  Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3'-->5' direction and involves coupling of 3'-Fmoc protected thiourea in the presence of HgCl2/TEA with the corresponding 5'-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00119-7