3-({4-[({4-[(cyclopropylmethyl)amino]-6-methoxynaphthalen-2-yl}carbonyl)amino]benzyl}amino)propanoic acid | 1622104-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-({4-[({4-[(cyclopropylmethyl)amino]-6-methoxynaphthalen-2-yl}carbonyl)amino]benzyl}amino)propanoic acid
• 英文别名: 3-[[4-[[4-(Cyclopropylmethylamino)-6-methoxynaphthalene-2-carbonyl]amino]phenyl]methylamino]propanoic acid
• CAS: 1622104-74-8
• 化学式: C₂₆H₂₉N₃O₄
• 分子量: 447.534
• InChiKey: USYTXUUQGXEQBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  99.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• SUBSTITUTED 6-METHOXY-4-AMINO-N-PHENYL-2-NAPHTAMIDES AS SPHINGOSINE RECEPTOR MODULATORS
  申请人：Allergan, Inc.

  公开号：US20140235592A1

  公开（公告）日：2014-08-21

  The present invention relates to substituted 6-methoxy-4-amino-N-phenyl-2-naphtamides derivatives, processes for preparing them, pharmaceutical compositions to containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

  本发明涉及取代的6-甲氧基-4-氨基-N-苯基-2-萘酰胺衍生物、其制备方法、含有它们的制药组合物以及它们作为调节鞘氨醇-1-磷酸受体的药物使用。
• [EN] SUBSTITUTED 6-METHOXY-4-AMINO-N-PHENYL-2-NAPHTAMIDES AS SPHINGOSINE RECEPTOR MODULATORS<br/>[FR] 6-MÉTHOXY-4-AMINO-N-PHÉNYL-2-NAPHTAMIDES SUBSTITUÉS EN TANT QUE MODULATEURS DES RÉCEPTEURS DE LA SPHINGOSINE
  申请人：ALLERGAN INC

  公开号：WO2014130572A1

  公开（公告）日：2014-08-28

  The present invention relates to substituted 6-methoxy-4-amino-N- phenyl-2-naphtamides derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. Claimed are compound represented by Formula, its enantiomers, diastereoisomers, tautomers, or a pharmaceutically acceptable salt thereof, a representative compound for formula I is: Example 9.