2.2'-dihydroxy-α.α'-diethyl-trans-stilbene | 74944-94-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2.2'-dihydroxy-α.α'-diethyl-trans-stilbene
• 英文别名: 2.2'-Dihydroxy-α.α'-diaethyl-trans-stilben；2,2'-Dihydroxy-α,β-diethylstilben；2-[(E)-4-(2-hydroxyphenyl)hex-3-en-3-yl]phenol
• CAS: 74944-94-8
• 化学式: C₁₈H₂₀O₂
• 分子量: 268.356
• InChiKey: VXQNNSGXYSGLOP-BUHFOSPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2.2'-dimethoxy-α.α'-diethyl-trans-stilbene 在 氢氧化钾 作用下， 生成 2.2'-dihydroxy-α.α'-diethyl-trans-stilbene
  参考文献：
  名称：

  Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1945, vol. 132, p. 83,95

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UN CARCINOME DE LA PROSTATE
  申请人：PELLFICURE PHARMACEUTICALS INC

  公开号：WO2016040896A1

  公开（公告）日：2016-03-17

  Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

  披露的是1,4-萘醌类似物，包括一个或多个这样的1,4-萘醌类似物的药物组合物，以及使用这些1,4-萘醌类似物治疗和/或改善与癌症相关的疾病和/或状况的方法，例如前列腺癌。还包括组合疗法，其中向患有癌症等状况的主体提供在本发明中披露的1,4-萘醌类似物和激素治疗剂。
• Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1945, vol. 132, p. 83,95
  作者：Dodds et al.

  DOI：——

  日期：——
• COMPOUNDS AND METHODS FOR TREATING PAIN
  申请人：Akron Molecules GmbH

  公开号：EP2637649A2

  公开（公告）日：2013-09-18
• COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA
  申请人：Pellficure Pharmaceuticals, Inc.

  公开号：EP3191087A1

  公开（公告）日：2017-07-19
• [EN] COMPOUNDS AND METHODS FOR TREATING PAIN<br/>[FR] COMPOSÉS ET PROCÉDÉS DE TRAITEMENT DE LA DOULEUR
  申请人：AKRON MOLECULES GMBH

  公开号：WO2012062925A2

  公开（公告）日：2012-05-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.