N-Octadecanoyl-sphingosin | 315710-06-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-Octadecanoyl-sphingosin
• 英文别名: N-Stearoyl-sphingosin；Ceramide；Ceramide (Brain, Porcine)；N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamide
• CAS: 315710-06-6
• 化学式: C₃₆H₇₁NO₃
• 分子量: 565.965
• InChiKey: VODZWWMEJITOND-OWWNRXNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.9
• 重原子数：
  40
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Sugar chain-containing water-soluble polymer compound
  申请人：Nishiguchi Susumu

  公开号：US20060287457A1

  公开（公告）日：2006-12-21

  A polymer compound having a monosaccharide or an oligosaccharide residue, or an amino acid or peptide residue bound to a monosaccharide or an oligosaccharide residue bound to a side chain of a water-soluble polymer through a linker containing a selectively cleavable bond, the water-soluble polymer containing 20 to 80 mol % of (meth)acrylic acid residue.

  这是一种聚合物化合物，它含有单糖或寡糖残基，或者氨基酸或肽残基与单糖或寡糖残基通过一个含有可选择断裂键的连接剂结合到水溶性聚合物的侧链上，其中水溶性聚合物含有20-80摩尔％的（甲基）丙烯酸残基。
• Method for producing glycoconjugates
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0897014A2

  公开（公告）日：1999-02-17

  A method for producing glycoconjugate, which comprises the steps of: (i) binding a sugar residue to the side chain of a water-soluble polymer via a linker having a selectively cleavable linkage to give a primer, and bringing said primer into contact with an immobilized glycosyltransferase in the presence of a sugar nucleotide, to transfer a sugar residue of said sugar nucleotide to the sugar residue of said primer, (ii) elongating a sugar chain by transfer of plural sugar residues by repeating the step (i) at least once, (iii) removing, where necessary, a by-produced nucleotide or an unreacted sugar nucleotide, and (iv) repeating the steps (i)-(iii) where necessary and releasing the glycoconjugate by selectively cleaving the cleavable linkage in the linker, from the above-mentioned primer connecting the sugar chain elongated by the transfer of plural sugar residues, and a method for producing a sphingoglycolipid.

  一种生产糖共轭物的方法，包括以下步骤 (i) 通过具有选择性可裂解连接的连接体，将糖残基与水溶性聚合物的侧链结合，得到引物，并在糖核苷酸存在的情况下，使所述引物与固定的糖基转移酶接触，将所述糖核苷酸的糖残基转移到所述引物的糖残基上、 (ii) 重复步骤(i)至少一次，通过转移多个糖残基拉长糖链、 (iii) 必要时去除副产核苷酸或未反应的糖核苷酸，以及 (iv) 必要时重复步骤(i)-(iii)，通过选择性地裂解连接体中的可裂解连接，从上述连接通过转移多个糖残基拉长的糖链的引物中释放出糖共轭物、 以及一种生产鞘氨醇糖脂的方法。
• CERAMIDASE GENE
  申请人：Takara Shuzo Co, Ltd.

  公开号：EP1172436A1

  公开（公告）日：2002-01-16

  A neutral/alkaline ceramidase derived from a mammal; an antibody specifically binding thereto; a probe and primer which are capable of specifically hybridizing thereto; a method for producing the ceramidase by a genetic engineering means; a method for detecting the ceramidase or the gene; and a method of controlling an amount of a ceramide in a cell and/or in a tissue. The present invention is useful as a reagent for lipid engineering for analyzing a structure, functions, and the like of a ceramide, and in its applications to diseases associated with the ceramide metabolism.

  一种来源于哺乳动物的中性/碱性神经酰胺酶；一种与之特异性结合的抗体；一种能够与之特异性杂交的探针和引物；一种通过基因工程手段生产神经酰胺酶的方法；一种检测神经酰胺酶或基因的方法；以及一种控制细胞和/或组织中神经酰胺数量的方法。本发明作为一种脂质工程试剂，可用于分析神经酰胺的结构、功能等，并可应用于与神经酰胺代谢有关的疾病。
• CERAMIDE DISPERSION AND METHOD FOR PRODUCING SAME
  申请人：FUJIFILM Corporation

  公开号：EP2361678A1

  公开（公告）日：2011-08-31

  The present invention provides a ceramide dispersion which includes (1) ceramide-containing particles which contains a ceramide, which are dispersed in an aqueous phase as an oil-phase component, and which have a volume average particle diameter from 1 nm to 100 nm; and (2) a fatty acid component which is at least one of a fatty acid having a melting temperature not higher than 30°C or a fatty acid salt; the amount of nonionic surfactant being 0 or not more than 0.1 times the total mass of the ceramide; the amount of an ionic surfactant other than the fatty acid component being 0 or less than 0.05 times the total mass of the ceramide; and the pH being from 6 to 8.

  本发明提供了一种神经酰胺分散液，其中包括：(1)含神经酰胺的颗粒，该颗粒含有神经酰胺，作为油相组分分散在水相中，颗粒的体积平均直径为1 nm至100 nm；(2)脂肪酸组分，该组分至少是熔点不高于30°C的脂肪酸或脂肪酸盐中的一种；非离子表面活性剂的用量为神经酰胺总质量的0或不超过0.1倍；脂肪酸组分以外的离子表面活性剂的用量为神经酰胺总质量的0或小于0.05倍；pH值为6至8。1 倍；除脂肪酸组分以外的离子表面活性剂的量为神经酰胺总质量的 0 或小于 0.05 倍；pH 值为 6 至 8。
• CERAMIDE DISPERSION, AND PROCESS FOR PRODUCING SAME
  申请人：FUJIFILM Corporation

  公开号：EP2380657A1

  公开（公告）日：2011-10-26

  The present invention provides a ceramide dispersion which includes (1) ceramide-containing particles which contain a ceramide, which are dispersed in an aqueous phase as an oil-phase component and which have a volume average particle diameter from 1 nm to 100 nm, (2) a fatty acid component which is at least one of a fatty acid and a fatty acid salt, (3) a polyhydric alcohol in an amount from 5 to 20 times larger than an amount of the ceramide and (4) a polysaccharide fatty acid ester; and in which the pH is from 6 to 8.

  本发明提供了一种神经酰胺分散液，其中包括：(1) 含神经酰胺的颗粒，该颗粒含有神经酰胺，作为油相组分分散在水相中，颗粒的体积平均直径为 1 纳米至 100 纳米；(2) 脂肪酸组分，该组分至少是脂肪酸和脂肪酸盐中的一种；(3) 多糖醇，其用量是神经酰胺用量的 5 至 20 倍；(4) 多糖脂肪酸酯；pH 值为 6 至 8。