5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthoyloxymethyl) - 2-thiophenecarboxylic acid | 139611-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthoyloxymethyl) - 2-thiophenecarboxylic acid
• 英文别名: 5-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalene-2-carbonyl)oxymethyl]thiophene-2-carboxylic acid
• CAS: 139611-78-2
• 化学式: C₂₁H₂₄O₄S
• 分子量: 372.485
• InChiKey: YTNPTZQMSXLLJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  91.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Composition pharmaceutique ou cosmétique contenant en association un rétinoîde et un stérol
  申请人：CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA

  公开号：EP0465343B1

  公开（公告）日：1994-06-15
• USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN
  申请人：Fabius Biotechnology

  公开号：US20210338558A1

  公开（公告）日：2021-11-04

  The present invention addresses the need for an improved delivery system that is able to specifically target the skin for improved bioavailability and minimization of side effects resulting from administration of the active ingredient or ingredients. One aspect of the present invention is a targeting composition comprising: (1) a skin care agent or an agent that is a cosmeceutical agent; (2) an intermediate release linker bound to the skin care agent or cosmeceutical agent; (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers; and (4) optionally, a carrier component to enhance delivery to the skin. The present invention also describes methods of use of these targeting compositions.
• US5387594A
  申请人：——

  公开号：US5387594A

  公开（公告）日：1995-02-07
• US5439925A
  申请人：——

  公开号：US5439925A

  公开（公告）日：1995-08-08
• US5567721A
  申请人：——

  公开号：US5567721A

  公开（公告）日：1996-10-22