((Z)-1-Ethoxy-oct-1-enyloxy)-trimethyl-silane | 126543-34-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: ((Z)-1-Ethoxy-oct-1-enyloxy)-trimethyl-silane
• CAS: 126543-34-8
• 化学式: C₁₃H₂₈O₂Si
• 分子量: 244.45
• InChiKey: QEJRYHWSRVTDEB-UHFFFAOYSA-N

物化性质

• 沸点：
  260.6±23.0 °C(Predicted)
• 密度：
  0.857±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.69
• 重原子数：
  16.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  ((Z)-1-Ethoxy-oct-1-enyloxy)-trimethyl-silane 在 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 2-羟基辛酸
  参考文献：
  名称：

  Role of the hydrophobic moiety of tumor promoters. Synthesis and activity of 2-alkylated benzolactams

  摘要：

  The size and position of a hydrophobic moiety on a benzolactam skeleton, which reproduces the active conformation and biological activity of teleocidins, play an important role in the appearance of the activity. Compounds with alkyl groups of various sizes and shapes at the 2-position of benzolactam were synthesized. Structure-activity results indicate that a hydrophobic substituent at the C-2 position plays a critical role in the appearance of biological activities, as in the case of substitution at C-9. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00580-6
• 作为产物：
  描述：

  三甲基氯硅烷 、 辛酸乙酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 ((Z)-1-Ethoxy-oct-1-enyloxy)-trimethyl-silane
  参考文献：
  名称：

  Role of the hydrophobic moiety of tumor promoters. Synthesis and activity of 2-alkylated benzolactams

  摘要：

  The size and position of a hydrophobic moiety on a benzolactam skeleton, which reproduces the active conformation and biological activity of teleocidins, play an important role in the appearance of the activity. Compounds with alkyl groups of various sizes and shapes at the 2-position of benzolactam were synthesized. Structure-activity results indicate that a hydrophobic substituent at the C-2 position plays a critical role in the appearance of biological activities, as in the case of substitution at C-9. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00580-6

文献信息

• Enantiomerically Pure Cyclopropyl Hemiacetals:  Lipase-Catalyzed Synthesis of Chiral, Nonracemic Ester Homoenolate Equivalents
  作者：Bernhard Westermann、Birte Krebs

  DOI：10.1021/ol006752f

  日期：2001.1.1

  Pseudomonas cepacia show enantiodivergent behavior toward these substrates. Subsequent ring opening of these building blocks can be achieved with ZnCl2 leading to chiral, nonracemic alpha-substituted homoenolate anions.

  对映体纯的环丙基半缩醛可以通过脂酶催化酰化同类物的动力学拆分而获得。已证明，来自南极假丝酵母和洋葱假单胞菌的脂肪酶对这些底物表现出对映异构行为。这些结构单元的随后开环可以用ZnCl 2实现，从而得到手性，非外消旋的α-取代的均烯酸酯阴离子。
• Preparation of .alpha.-fluorocarboxylic acids and derivatives
  作者：Suzanne T. Purrington、Daniel L. Woodard

  DOI：10.1021/jo00297a090

  日期：1990.5