4-[(3-carbamoylmethoxy-phenylcarbamoyl)-methoxy]-5,7-dichloro-naphthalene-2-carboxylic acid | 1257343-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[(3-carbamoylmethoxy-phenylcarbamoyl)-methoxy]-5,7-dichloro-naphthalene-2-carboxylic acid
• 英文别名: 4-[2-[3-(2-Amino-2-oxoethoxy)anilino]-2-oxoethoxy]-5,7-dichloronaphthalene-2-carboxylic acid
• CAS: 1257343-55-7
• 化学式: C₂₁H₁₆Cl₂N₂O₆
• 分子量: 463.274
• InChiKey: DHEFBQOYRQBDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  128
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] GLYCINE B ANTAGONISTS<br/>[FR] ANTAGONISTES DE LA GLYCINE B
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2010139481A1

  公开（公告）日：2010-12-09

  The invention relates to naphthalene derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

  该发明涉及萘衍生物以及它们的药用可接受盐。该发明还涉及一种制备这些化合物的方法。该发明的化合物是甘氨酸B拮抗剂，因此对于控制和预防各种疾病，包括神经系统疾病，具有用处。
• GLYCINE B ANTAGONISTS
  申请人：Henrich Markus

  公开号：US20120220577A1

  公开（公告）日：2012-08-30

  The invention relates to naphthalene derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

  本发明涉及萘衍生物及其药学上可接受的盐。本发明还涉及一种制备这些化合物的方法。本发明中的化合物是甘氨酸B拮抗剂，因此对于控制和预防各种疾病，包括神经系统疾病，非常有用。