3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-4-methoxy-4-methylpentanoic acid | 1402936-63-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-4-methoxy-4-methylpentanoic acid
• 英文别名: US10023528, Example 25；3-[4-chloro-3-[[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino]phenyl]-4-methoxy-4-methylpentanoic acid
• CAS: 1402936-63-3
• 化学式: C₂₄H₂₆Cl₂F₃NO₄
• 分子量: 520.376
• InChiKey: SYOVPNRDQAHFAQ-KVCBOLPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Branched 3-phenylpropionic acid derivatives and their use
  申请人：HAHN Michael

  公开号：US20130079412A1

  公开（公告）日：2013-03-28

  The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

  本申请涉及携带在3位的支链或环状烷基取代基的新型3-苯丙酸衍生物，涉及它们的制备方法，涉及它们用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• VERZWEIGTE 3-PHENYLPROPIONSÄURE-DERIVATE UND IHRE VERWENDUNG
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2697191B1

  公开（公告）日：2015-11-18
• BRANCHED 3-PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE
  申请人：BAYER INTELLECTUAL PROPERTY GMBH

  公开号：US20190185415A1

  公开（公告）日：2019-06-20

  The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
• US8796335B2
  申请人：——

  公开号：US8796335B2

  公开（公告）日：2014-08-05