biotin-N-(1-propyl)amide | 41994-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: biotin-N-(1-propyl)amide
• 英文别名: 5-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-pentanoic acid propylamide；biotin propylamide；2-Biotinoylaminoethylmethane；5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-propylpentanamide
• CAS: 41994-01-8
• 化学式: C₁₃H₂₃N₃O₂S
• 分子量: 285.411
• InChiKey: TULLSVIZKKYXJY-NHCYSSNCSA-N

物化性质

• 沸点：
  596.6±35.0 °C(Predicted)
• 密度：
  1.125±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丙胺 、 D-生物素 在 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 生成 biotin-N-(1-propyl)amide
  参考文献：
  名称：

  Biotin Derivatives as Gelators of Organic Solvents

  摘要：

  The preparation of a series of biotin esters and amides is described. Several of these compounds are capable of forming stable gels with a variety of organic solvents.

  DOI：

  10.1080/00397919708003373

文献信息

• [EN] COMPOUNDS AND THERAPEUTIC USES THEREOF<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：CENTAURI THERAPEUTICS LTD

  公开号：WO2017060729A1

  公开（公告）日：2017-04-13

  The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and a disease or disorder mediated and/or caused by an infective agent, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.

  该发明涉及具有将免疫反应与特定治疗靶标联系起来的新化合物，以及将该类化合物用于治疗癌症、由感染性因子介导和/或引起的疾病或紊乱，包含该类化合物的组合物，其制备过程以及用于该过程的新中间体。
• Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use
  申请人：Rajski R. Scott

  公开号：US20070161007A1

  公开（公告）日：2007-07-12

  The present invention discloses compounds and methods used to specifically target substrates of methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases. The substrates can be peptides, single stranded nucleic acids or double stranded nucleic acids, including RNA, DNA and PNA or phospholipids. The compounds disclosed are SAM analogs that are ligated to a methylation site by the methyltransferase. Also disclosed, are reacting groups that are ligatable to the cofactor analogs and can also be used as detectable labels. The reacting group can be used to cleave the substrate providing a methylation footprint. The invention can be used clinically to determine methylation state of a gene or gene promoter such as those involved in imprinting and transcription. In some preferred embodiments, the invention includes a kit, which can include one or more suitable SAM analogs and may include one or more detectable labels. In other preferred embodiments, the invention includes a pharmaceutical composition.

  本发明揭示了化合物和方法，用于特异性靶向S-腺苷基-L-甲硫氨酸（SAM）依赖的甲基转移酶的甲基化底物。这些底物可以是肽、单链核酸或双链核酸，包括RNA、DNA和PNA或磷脂。所揭示的化合物是SAM类似物，它们通过甲基转移酶与甲基化位点连接。此外，还揭示了可与辅因子类似物连接的反应基团，也可用作可检测标记。反应基团可用于裂解底物，提供甲基化足迹。本发明可用于临床上确定基因或基因启动子的甲基化状态，例如涉及印迹和转录的基因。在一些优选实施例中，本发明包括一个试剂盒，其中可以包括一个或多个适当的SAM类似物，也可以包括一个或多个可检测标记。在其他优选实施例中，本发明包括一种制药组合物。
• Lanthanide toolbox for organelle specific molecular imaging with multi-color
  申请人：New Life Medicine Technology Company Limited

  公开号：US10787465B2

  公开（公告）日：2020-09-29

  Provided herein are lanthanide complexes that exhibit specific subcellular localization to primary cilium. The lanthanide complexes provided herein are useful for imaging, tagging, and pull down of binding targets located in primary cilium.

  本文所提供的镧系元素复合物可在初级纤毛膜上显示特异性亚细胞定位。本文提供的镧系元素复合物可用于对位于初级纤毛膜中的结合目标进行成像、标记和下拉。
• McCormick,D.B., Journal of Heterocyclic Chemistry, 1973, vol. 10, p. 235 - 237
  作者：McCormick,D.B.

  DOI：——

  日期：——
• AFFINITY BASED DRUG RELEASE FORMULATIONS
  申请人：McMaster University

  公开号：US20170368033A1

  公开（公告）日：2017-12-28

  The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.