2-amino-3-[2-(4-fluorophenyl)ethyl]benzoic Acid | 345915-23-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-amino-3-[2-(4-fluorophenyl)ethyl]benzoic Acid
• CAS: 345915-23-3
• 化学式: C₁₅H₁₄FNO₂
• 分子量: 259.27
• InChiKey: INVALIZXSWWKSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Farnesyl transferase inhibitors
  申请人：——

  公开号：US20030083348A1

  公开（公告）日：2003-05-01

  1 This invention relates to compounds of formula (1) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.

  这项发明涉及抑制法尼基化酶（FPTase）从而抑制基因产物法尼基化的公式（1）化合物的制备方法。该发明还涉及制造这些化合物、药物组合物以及治疗特别是通过法尼基化介导的癌症等疾病的方法。
• FARNESYL TRANSFERASE INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1255733A1

  公开（公告）日：2002-11-13
• US7101897B2
  申请人：——

  公开号：US7101897B2

  公开（公告）日：2006-09-05
• [EN] FARNESYL TRANSFERASE INHIBITORS<br/>[FR] INHIBITEURS DE FARNESYLTRANSFERASE
  申请人：ASTRAZENECA AB

  公开号：WO2001046137A1

  公开（公告）日：2001-06-28

  This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.