N-((3R)-1-azabicyclo[2.2.2]oct-3-yl)-1H-indazole-6-carboxamide | 478169-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: N-((3R)-1-azabicyclo[2.2.2]oct-3-yl)-1H-indazole-6-carboxamide
• 英文别名: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-1H-indazole-6-carboxamide；N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-1H-indazole-6-carboxamide
• CAS: 478169-75-4
• 化学式: C₁₅H₁₈N₄O
• 分子量: 270.334
• InChiKey: OYCAIFKXULCOPU-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  61
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Quinuclidine-substituted hetero-bicyclic aromatic compounds for the treatment of disease
  申请人：——

  公开号：US20030073707A1

  公开（公告）日：2003-04-17

  The invention provides compounds of Formula I: 1 wherein W 0 is a bicyclic moiety and is 2 These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful to treat diseases or conditions in which &agr;7 is known to be involved.

  这项发明提供了Formula I的化合物： 其中W0是一个双环基团，是 这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或混合物，对治疗已知涉及α7的疾病或症状有用。
• [EN] INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF<br/>[FR] INDAZOLES, BENZOTHIAZOLES ET BENZOISOTHIAZOLES, LEUR PREPARATION ET LEURS UTILISATIONS
  申请人：MEMORY PHARM CORP

  公开号：WO2004029050A1

  公开（公告）日：2004-04-08

  The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

  本发明涉及一般与尼古丁乙酰胆碱受体（nAChR）的配体、nAChR的激活以及与缺陷或功能失常的尼古丁乙酰胆碱受体相关的疾病病况的领域。此外，该发明涉及新颖化合物（吲唑和苯并噻唑），它们作为α7 nAChR亚型的配体，制备这类化合物的方法，含有这类化合物的组合物，以及使用这些方法。
• Treatment of diseases with combinations of alpha 7 Nicotinic Acetylcholine Receptor agonists and other compounds
  申请人：Corbett W. Jeffrey

  公开号：US20050245504A1

  公开（公告）日：2005-11-03

  The present invention relates to compositions and methods to treat diseases or condition with an α7 nAChR full agonist and an inhibitor of cholinesterase, and or beta secretase and or gamma secretase.

  本发明涉及利用α7 nAChR全激动剂和胆碱酯酶抑制剂，和/或beta秘鲁和/或gamma秘鲁的组合物和方法来治疗疾病或症状。
• Treatment of attention defecit hyperactivity disorder
  申请人：Rogers N. Bruce

  公开号：US20050107425A1

  公开（公告）日：2005-05-19

  The present invention relates to compositions and methods to treat ADHD with an α7 nAChR full agonist and psychostimulants and/or monoamine reuptake inhibitors.

  本发明涉及使用α7 nAChR全激动剂和精神刺激剂和/或单胺再摄取抑制剂的组合物和方法来治疗ADHD。
• Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
  申请人：——

  公开号：US20040132790A1

  公开（公告）日：2004-07-08

  The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the &agr;7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

  本发明通常涉及乙酰胆碱受体配体（nAChR）、nAChR激活以及与缺陷或功能障碍的乙酰胆碱受体相关的疾病状态的治疗领域，特别是大脑。此外，本发明涉及新型化合物（吲唑和苯并噻唑），其作为α7 nAChR亚型的配体，制备此类化合物的方法，含有此类化合物的组合物，以及使用此类化合物的方法。