2,7-Dimethylnaphthoresorcin | 33253-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,7-Dimethylnaphthoresorcin
• 英文别名: 2,7-Dimethylnaphthalene-1,3-diol
• CAS: 33253-98-4
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: AFCUSINNHADUQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• KRAS G12C INHIBITORS
  申请人：Mirati Therapeutics, Inc.

  公开号：US20210230170A1

  公开（公告）日：2021-07-29

  The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
• [EN] CYCLIC COMPOUNDS CONTAINING ZINC BINDING GROUPS AS MATRIX METALLOPROTEINASE INHIBITORS<br/>[FR] COMPOSES CYCLIQUES CONTENANT DES GROUPES LIANT LE ZINC EN TANT QU'INHIBITEURS DE METALLOPROTEASE DE MATRICE
  申请人：WARNER LAMBERT CO

  公开号：WO2004014384A2

  公开（公告）日：2004-02-19

  This invention provides compounds defined by Formula I Z-L-R1-Q-D-(V1)m-R2 I or a pharmaceutically acceptable salt thereof, wherein Z, L, R1, Q, D, V1, m, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I and the use of the compounds of Formula I as MMP-B inhibitors.