(-)-[(5R)-cis]-4-[4-[4-[4-[[5-(2,4-Difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(1S)-(1-methylpropyl)]-3H-1,2,4-triazol-3-one | 160709-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (-)-[(5R)-cis]-4-[4-[4-[4-[[5-(2,4-Difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(1S)-(1-methylpropyl)]-3H-1,2,4-triazol-3-one
• 英文别名: 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1,5-dihydro-1-[(1R)-1-methylpropyl]-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol；2-butan-2-yl-4-[4-[4-[4-[[5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
• CAS: 160709-03-5
• 化学式: C₃₆H₄₀F₂N₈O₃
• 分子量: 670.762
• InChiKey: VBXIEZVFKHTISY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  49
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Enhanced delivery of antifungal agents
  申请人：Keller Brian Charles

  公开号：US20090176795A1

  公开（公告）日：2009-07-09

  Tetrahydrofuran antibiotics formulated with certain diacylglycerol-poltethyleneglycol (DAG-PEG) lipids have increased water solubility and bioavailabilty. PEG-12 GDO, PEG-12 GDLO, PEG-12 GDM and PEG-12 GDP are particularly suitable for forming liposomes that incorporate tetrahydroflurans in the bilayer.
• PEG-lipid conjugates for liposomes and drug delivery
  申请人：Wu Nian

  公开号：US20100076209A1

  公开（公告）日：2010-03-25

  New diacylglycerol-polyethylene glycol (DAG-PEG) conjugates are described. A variety of linkers between the PEG chain and glycerol backbone of the DAG-PEGs may be selected to optimize liposomal formulations of pharmaceuticals and cosmetics.
• US8304565B2
  申请人：——

  公开号：US8304565B2

  公开（公告）日：2012-11-06
• [EN] ENHANCED DELIVERY OF ANTIFUNGAL AGENTS<br/>[FR] DÉLIVRANCE AMÉLIORÉE D'AGENTS ANTIFONGIQUES
  申请人：KELLER BRIAN CHARLES

  公开号：WO2009088959A1

  公开（公告）日：2009-07-16

  Tetrahydrofiiran antibiotics formulated with certain diacylglycerol- poltethyleneglycol (DAG-PEG) lipids have increased water solubility and bioavailabilty. PEG- 12 GDO, PEG- 12 GDLO, PEG- 12 GDM and PEG- 12 GDP are particularly suitable for forming liposomes that incorporate tetrahydrofurans in the bilayer.