3-phenylnaphthalic anhydride | 181779-85-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-phenylnaphthalic anhydride
• 英文别名: 7-Phenyl-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaene-2,4-dione
• CAS: 181779-85-1
• 化学式: C₁₈H₁₀O₃
• 分子量: 274.276
• InChiKey: QLCKBDQCZWJRCZ-UHFFFAOYSA-N

物化性质

• 熔点：
  >250 °C
• 沸点：
  513.3±29.0 °C(predicted)
• 密度：
  1.358±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N'-二(2-氨乙基)-1,3-丙二胺 、 3-phenylnaphthalic anhydride 以 氯仿 为溶剂， 反应 24.0h， 以62%的产率得到N,N'-bis{2-[5-phenyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinol-5-yl]ethyl}-1,3-propanodiamine
  参考文献：
  名称：

  Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives

  摘要：

  A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.

  DOI：

  10.1021/jm0310784
• 作为产物：
  描述：

  3-溴-1,8-萘二甲酸酐 、 三丁基苯基锡 在 四(三苯基膦)钯 作用下， 以 1,4-二氧六环 为溶剂， 反应 48.0h， 以84%的产率得到3-phenylnaphthalic anhydride
  参考文献：
  名称：

  Synthesis, Biological Activity, and Quantitative Structure−Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives

  摘要：

  A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.

  DOI：

  10.1021/jm0310784

文献信息

• Reduction of carbonyl compounds using the carbonyl reductase of kluyveromyces marxianus
  申请人：Korea Institute of Science and Technology

  公开号：US20030139464A1

  公开（公告）日：2003-07-24

  A compound represented by a genera formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus . The compound can be prepared by reduction of substituted &bgr;-keto ester and can be used as an intermediate in preparing &bgr;-lactam group antibiotics. 1

  由一般化学式(Ia)或(Ib)代表的化合物及其立体选择性制备方法，使用从马氏克鲁维酵母中分离的羰基还原酶。该化合物可通过还原取代的β-酮酯制备，并可用作制备β-内酰胺类抗生素中间体。
• US7094908B2
  申请人：——

  公开号：US7094908B2

  公开（公告）日：2006-08-22