2-(4--2-butynyl)-2-methylcyclohexane-1,3-dione | 110797-00-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-(4--2-butynyl)-2-methylcyclohexane-1,3-dione
• CAS: 110797-00-7
• 化学式: C₁₇H₂₈O₃Si
• 分子量: 308.493
• InChiKey: NQUAFEJVGKZSNQ-UHFFFAOYSA-N

物化性质

• 沸点：
  383.1±32.0 °C(Predicted)
• 密度：
  0.985±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(4--2-butynyl)-2-methylcyclohexane-1,3-dione 在 氢氟酸 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以87%的产率得到2-(4-hydroxy-2-butynyl)-2-methylcyclohexane-1,3-dione
  参考文献：
  名称：

  Use of metal complexation in the synthesis of medium-ring acetylenic lactones

  摘要：

  The hexacarbonyldicobalt complexes of several appropriately designed acetylenic lactone precursors have been prepared, and lactones containing Co2(CO)6-complexed triple bonds in seven-, ten-, and eleven-membered rings obtained. The latter were best obtained through a retro-Dieckmann fragmentation of 2-(hydroxybutynyl) derivatives of 1,3-cyclohexanedione. Attempts to extend this reaction to cyclohexanones bearing other anion-stabilizing groups in the 2-position or to 1,3-cyclopentanediones were unsuccessful. Decomplexation afforded the metal-free 11-ring lactone, characterized crystallographically. Treatment of this system with basic reagents led to dimerization. In the case of the smaller rings, cyclization of the complexed acetylenic hydroxyacids under Mukaiyama conditions (2-chloro-N-methylpyridinium iodide, CH2Cl2, reflux) succeeded in modest yields.

  DOI：

  10.1016/0022-328x(92)83338-i
• 作为产物：
  描述：

  4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol 在 四溴化碳 、 sodium hydride 、 三苯基膦 作用下， 以 乙醚 为溶剂， 反应 21.25h， 生成 2-(4--2-butynyl)-2-methylcyclohexane-1,3-dione
  参考文献：
  名称：

  Use of metal complexation in the synthesis of medium-ring acetylenic lactones

  摘要：

  The hexacarbonyldicobalt complexes of several appropriately designed acetylenic lactone precursors have been prepared, and lactones containing Co2(CO)6-complexed triple bonds in seven-, ten-, and eleven-membered rings obtained. The latter were best obtained through a retro-Dieckmann fragmentation of 2-(hydroxybutynyl) derivatives of 1,3-cyclohexanedione. Attempts to extend this reaction to cyclohexanones bearing other anion-stabilizing groups in the 2-position or to 1,3-cyclopentanediones were unsuccessful. Decomplexation afforded the metal-free 11-ring lactone, characterized crystallographically. Treatment of this system with basic reagents led to dimerization. In the case of the smaller rings, cyclization of the complexed acetylenic hydroxyacids under Mukaiyama conditions (2-chloro-N-methylpyridinium iodide, CH2Cl2, reflux) succeeded in modest yields.

  DOI：

  10.1016/0022-328x(92)83338-i

文献信息

• Preparation of medium-ring acetylenic lactones utilizing metal-promoted alkyne bending
  作者：Neil E. Schore、Samir D. Najdi

  DOI：10.1021/jo00232a050

  日期：1987.11