2-(6-carbomethoxy-1,4-dithiahexyl)-4-(R)-tert-butyldimethylsilyloxy-2-cyclopentenone | 433213-06-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-(6-carbomethoxy-1,4-dithiahexyl)-4-(R)-tert-butyldimethylsilyloxy-2-cyclopentenone
• CAS: 433213-06-0
• 化学式: C₁₇H₃₀O₄S₂Si
• 分子量: 390.64
• InChiKey: KVNPIQSMFPIJNF-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  24.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2-(6-carbomethoxy-1,4-dithiahexyl)-4-(R)-tert-butyldimethylsilyloxy-2-cyclopentenone 在 porcine liver esterase 、 (HF)n*Py 、 叔丁基锂 作用下， 以 吡啶 、 phosphate buffer 、 乙醚 、 乙醇 、 乙腈 、 正戊烷 为溶剂， 反应 6.5h， 生成 3-{2-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentylsulfanyl]-ethylsulfanyl}-propionic acid
  参考文献：
  名称：

  Design and synthesis of a selective EP4-Receptor agonist. Part 1: discovery of 3,7-DithiaPGE1 derivatives and identification of Their ω chains

  摘要：

  Improvement of EP4-receptor selectivity and the agonist activity by introduction of heteroatoms into the a chain of PGE(1) was investigated. Among the compounds tested, 3,7-dithiaPGE(1) 4a exhibited good EP4-receptor selectivity and agonist activity. Further modification of the omega chain of 3,7-dithiaPGE(1) was performed to improve EP4-receptor selectivity and agonist activity. Of the compounds produced, 16-phenyl-omega-tetranor-3.7-dithiaPGE(1) 4p possessing moderate EP4-receptor selectivity and agonist activity. was identified as a new chemical lead for further optimization by modification of the aromatic moiety. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00351-0
• 作为产物：
  描述：

  (4R)-tert-butyldimethylsilyloxy-2,3-epoxycyclopentanone 、 methyl 6-mercapto-4-thiahexanoate 在 aluminum oxide 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 以77%的产率得到2-(6-carbomethoxy-1,4-dithiahexyl)-4-(R)-tert-butyldimethylsilyloxy-2-cyclopentenone
  参考文献：
  名称：

  Design and synthesis of a selective EP4-Receptor agonist. Part 1: discovery of 3,7-DithiaPGE1 derivatives and identification of Their ω chains

  摘要：

  Improvement of EP4-receptor selectivity and the agonist activity by introduction of heteroatoms into the a chain of PGE(1) was investigated. Among the compounds tested, 3,7-dithiaPGE(1) 4a exhibited good EP4-receptor selectivity and agonist activity. Further modification of the omega chain of 3,7-dithiaPGE(1) was performed to improve EP4-receptor selectivity and agonist activity. Of the compounds produced, 16-phenyl-omega-tetranor-3.7-dithiaPGE(1) 4p possessing moderate EP4-receptor selectivity and agonist activity. was identified as a new chemical lead for further optimization by modification of the aromatic moiety. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00351-0