(S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone | 1615700-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone
• 英文别名: [4-(2-hydroxyethyl)piperazin-1-yl]-[(2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]methanone
• CAS: 1615700-34-9
• 化学式: C₂₀H₃₀N₂O₄
• 分子量: 362.469
• InChiKey: YJSWNTCSQVPWRJ-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.54
• 重原子数：
  26.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  73.24
• 氢给体数：
  2.0
• 氢受体数：
  5.0

文献信息

• [EN] COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：SULFATEQ BV

  公开号：WO2021118359A1

  公开（公告）日：2021-06-17

  The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of Alzheimer's disease and/or for improving memory function and/or reducing plaque load. Specifically, the present invention relates to chromanol compounds chosen from (6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-5 yl)methanone, ((S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2- carboxamide hydrochloride and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2- hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.
• [EN] CHROMANOL, QUINONE OR HYDROQUINONE COMPOUNDS FOR TREATMENT OF SEPSIS<br/>[FR] COMPOSÉS CHROMANOL, QUINONE OU HYDROQUINONE POUR LE TRAITEMENT DE LA SEPTICÉMIE
  申请人：SULFATEQ BV

  公开号：WO2021246868A1

  公开（公告）日：2021-12-09

  The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of sepsis and sepsis-induced organ dysfunction. Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8- tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8- tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.