2-<2-Methoxy-phenylaethinyl>-benzofuran | 109256-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-<2-Methoxy-phenylaethinyl>-benzofuran
• 英文别名: 2-(2-methoxy-phenylethynyl)-benzofuran；2-[2-(2-Methoxyphenyl)ethynyl]-1-benzofuran；2-[2-(2-methoxyphenyl)ethynyl]-1-benzofuran
• CAS: 109256-05-5
• 化学式: C₁₇H₁₂O₂
• 分子量: 248.281
• InChiKey: HIKXWGVWEJHGSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  22.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,1-dibromo-2-(2-methoxyphenyl)ethene 在 tris-(dibenzylideneacetone)dipalladium(0) 、 copper(l) iodide 、 三(2-呋喃基)膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以39%的产率得到1,4-bis(2-methoxyphenyl)-1,3-butadiyne
  参考文献：
  名称：

  Synthesis of 1,3-Diynes via Palladium-Catalyzed Reaction of 1,1-Dibromo-1-alkenes

  摘要：

  Both symmetric and unsymmetric 1,3-diynes were prepared from the palladium-catalyzed reaction of 1,l-dibromo-l-alkenes. The formation of symmetric 1,3-diynes 2 (homocoupling) was catalyzed by a weak ligand, tris(2-furyl)phosphine (TFP), and the addition of catalytic amount of Cul accelerated the reaction. The synthesis of unsymmetric 1,3-diynes 4 (the Sonogashira reaction) required a highly electron rich tris(4-methoxyphenyl)phosphine as the ligand, and Cul promotes the formation of byproduct 1,1-diynyl-1-alkenes 5.

  DOI：

  10.1021/ol006282p

文献信息

• Synthesis of 1,3-Diynes via Palladium-Catalyzed Reaction of 1,1-Dibromo-1-alkenes
  作者：Wang Shen、Sheela A. Thomas

  DOI：10.1021/ol006282p

  日期：2000.9.1

  Both symmetric and unsymmetric 1,3-diynes were prepared from the palladium-catalyzed reaction of 1,l-dibromo-l-alkenes. The formation of symmetric 1,3-diynes 2 (homocoupling) was catalyzed by a weak ligand, tris(2-furyl)phosphine (TFP), and the addition of catalytic amount of Cul accelerated the reaction. The synthesis of unsymmetric 1,3-diynes 4 (the Sonogashira reaction) required a highly electron rich tris(4-methoxyphenyl)phosphine as the ligand, and Cul promotes the formation of byproduct 1,1-diynyl-1-alkenes 5.