5,7-Dihydroxy-2-methyl-6-(pyridin-2-yliminomethyl)chromen-4-one | 1377148-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5,7-Dihydroxy-2-methyl-6-(pyridin-2-yliminomethyl)chromen-4-one
• CAS: 1377148-73-6
• 化学式: C₁₆H₁₂N₂O₄
• 分子量: 296.282
• InChiKey: NRNCRCOJUHVTTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  7-羟基-5-甲氧基-2-甲基-4-氧代-4H-1-苯并吡喃-6-甲醛 在 盐酸 、 水 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 5,7-Dihydroxy-2-methyl-6-(pyridin-2-yliminomethyl)chromen-4-one
  参考文献：
  名称：

  Microplate assay for screening the antibacterial activity of Schiff bases derived from substituted benzopyran-4-one

  摘要：

  Schiff bases (SB1-SB3) were synthesized from the condensation of 6-formyl-7-hydroxy-5-methoxy2-methylbenzopyran-4-one with 2-aminopyridine (SB1), p-phenylenediamine (SB2) and o-phenylenediamine (SB3), while Schiff bases (SB4-SB6) were synthesized by condensation of 5,7-dihydroxy-6-formyl-2-methylbenzopyran-4-one with 2-aminopyridine (SB4), p-phenylenediamine (SB5) and o-phenylenediamine (SB6). Schiff bases were characterized using elemental analysis, IR, UV-Vis, H-1 NMR, C-13 NMR and mass spectroscopy. These compounds were screened for antibacterial activities by micro-plate assay technique. Escherichia coli and Staphylococcus capitis were exposed to different concentrations of the Schiff bases. Results showed that the antibacterial effect of these Schiff bases on Gram-negative bacteria were higher than that on Gram-positive bacteria moreover, the Schiff bases containing substituent OCH3 on position five have higher antibacterial activity than that containing hydroxy group on the same position, (C) 2012 Elsevier By. All rights reserved.

  DOI：

  10.1016/j.saa.2012.04.042