8-chloro-isochroman-1,3-dione | 1075716-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-chloro-isochroman-1,3-dione
• 英文别名: 8-chlorohomophthalic anhydride；8-chloro-3,4-dihydro-1H-2-benzopyran-1,3-dione；8-chloro-4H-isochromene-1,3-dione
• CAS: 1075716-31-2
• 化学式: C₉H₅ClO₃
• 分子量: 196.59
• InChiKey: HMFLQANNQRLZMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS
  申请人：Simonsen Klaus Baek

  公开号：US20090143402A1

  公开（公告）日：2009-06-04

  Isoquinolone derivatives of the general formula are provided. The compounds are NK3 antagonists and useful for the treatment of e.g. psychosis and schizophrenia.

  提供了一般化合物的异喹啉衍生物。这些化合物是NK3拮抗剂，可用于治疗精神病和精神分裂症等疾病。
• [EN] ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS<br/>[FR] DÉRIVÉS D'ISOQUINOLINONE EN TANT QU'ANTAGONISTES DES RÉCEPTEURS NK3
  申请人：LUNDBECK & CO AS H

  公开号：WO2010028655A1

  公开（公告）日：2010-03-18

  The invention relates to isoquinolinone derivatives useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

  这项发明涉及对异喹啉酮衍生物的利用，特别是在治疗精神病方面，涉及包含所述化合物的组合物，以及通过给予所述化合物来治疗疾病的方法。
• NOVEL INHIBITORS OF FLAVIVIRUS REPLICATION
  申请人：Bardiot Dorothée

  公开号：US20110224208A1

  公开（公告）日：2011-09-15

  The present invention relates to a series of Isoquinolone derivatives which are suitable to treat infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Hepatitis C virus (HCV). The present invention also relates to Isoquinolone compounds for use as a medicine for the prevention or treatment of viral infections, preferably infections with viruses belonging to the family of the Flaviviridae.

  本发明涉及一系列异喹啉衍生物，适用于治疗属于黄病毒科家族的病毒感染，更优选地是治疗丙型肝炎病毒（HCV）感染。本发明还涉及异喹啉化合物作为预防或治疗病毒感染的药物，优选是治疗属于黄病毒科家族的病毒感染。
• 1,4-Benzodiazepone-2,5-Diones And Related Compounds With Therapeutic Properties
  申请人：The Regents of the University of Michigan

  公开号：US20160095866A1

  公开（公告）日：2016-04-07

  The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.

  本发明提供了新型化学化合物，其特征为Rho激酶（ROCK）抑制剂，以及发现这些化合物的方法和它们的治疗、研究和诊断用途。特别地，本发明提供了具有ROCK抑制活性的1,4-苯二氮平-2,5-二酮化合物和相关化合物，并提供了使用这些化合物作为治疗剂治疗与ROCK活性相关的多种疾病的方法。
• Method for tracking compounds in solution phase combinatorial chemistry
  申请人：——

  公开号：US20020098598A1

  公开（公告）日：2002-07-25

  A method for the generation of chemical libraries using machine-readable passive tagging systems is described. The preferred embodiment uses radiofrequency tags or one- or two-dimensional bar codes to track vials and the contents therein throughout the course of the synthesis. This abrogates the need for specialized combinatorial chemistry equipment, allowing the use of standard laboratory baths, ovens, shakers and racks, as well as manual fluid handling techniques.

  本文介绍了一种利用机器可读无源标签系统生成化学库的方法。优选的实施方案使用射频标签或一维或二维条形码在整个合成过程中跟踪小瓶及其中的内容物。这样就不需要专门的组合化学设备，可以使用标准的实验室浴槽、烤箱、振动器和架子，以及人工液体处理技术。