(R)-6-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-5-(3-fluoro-4-(1H-indazol-4-yl)phenyl)-4,6-diazaspiro[2.4]hept-4-en-7-one | 1579516-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: (R)-6-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-5-(3-fluoro-4-(1H-indazol-4-yl)phenyl)-4,6-diazaspiro[2.4]hept-4-en-7-one
• 英文别名: 6-[[(3R)-1-(cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-5-[3-fluoro-4-(1H-indazol-4-yl)phenyl]-4,6-diazaspiro[2.4]hept-4-en-7-one
• CAS: 1579516-99-6
• 化学式: C₂₇H₂₆FN₅O₂
• 分子量: 471.534
• InChiKey: FITCORZQLZPVJO-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS D'IMIDAZOLINE-5-ONE UTILES EN TANT QU'INHIBITEURS DE L'ACIDE GRAS SYNTHASE (FASN) POUR LE TRAITEMENT DU CANCER
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014039769A1

  公开（公告）日：2014-03-13

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L1, a, b, m, n, R1, R2, R3, R4, and R5 are defined herein.

  披露了用于治疗多种疾病、综合征、状况和失调的化合物、组合物和方法，包括那些通过抑制脂肪酸合酶（FASN）酶介导的疾病，例如癌症、肥胖或相关失调以及肝脏相关失调。这些化合物由公式（I）表示，如下所示：其中L1、a、b、m、n、R1、R2、R3、R4和R5在此定义。
• IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Janssen Pharmaceutica NV

  公开号：US20160002219A1

  公开（公告）日：2016-01-07

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L 1 , a, b, m, n, R 1 , R 2 , R 3 , R 4 , and R 5 are defined herein.

  本发明涉及化合物、组合物和方法，用于治疗各种疾病、综合症、病况和障碍，包括由脂肪酸合成酶（FASN）酶抑制介导的疾病，例如癌症、肥胖或相关障碍和肝脏相关障碍。这些化合物由以下式（I）表示：其中L1、a、b、m、n、R1、R2、R3、R4和R5的定义如下。
• IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Janssen Pharmaceutica NV

  公开号：EP2892892B1

  公开（公告）日：2017-05-31