3-(2-(benzo[d][1,3]dioxol-5-yl)-6-tert-butoxypyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine | 1357002-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 3-(2-(benzo[d][1,3]dioxol-5-yl)-6-tert-butoxypyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine
• 英文别名: 3-[2-(1,3-benzodioxol-5-yl)-6-[(2-methylpropan-2-yl)oxy]pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine
• CAS: 1357002-60-8
• 化学式: C₂₃H₂₁N₃O₃
• 分子量: 387.438
• InChiKey: DOBNHPJHJBTZBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRROLOPYRIDINE INHIBITORS OF KINASES
  申请人：AbbVie Inc.

  公开号：US20140357616A1

  公开（公告）日：2014-12-04

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1a , R 1b , R 1c , X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

  本发明涉及公式（I）的化合物或药学上可接受的盐，其中R1a，R1b，R1c，X和Y在说明中有定义。本发明还涉及含有所述化合物的组合物，该组合物对于抑制Cdc7等激酶以及治疗癌症等疾病具有用处的方法。
• US8822446B2
  申请人：——

  公开号：US8822446B2

  公开（公告）日：2014-09-02
• US9181246B2
  申请人：——

  公开号：US9181246B2

  公开（公告）日：2015-11-10
• [EN] PYRROLOPYRIDINE INHIBITORS OF KINASES<br/>[FR] INHIBITEURS PYRROLOPYRIDINE DE KINASES
  申请人：ABBOTT LAB

  公开号：WO2011133388A1

  公开（公告）日：2011-10-27

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, Formula (I) wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.