(+)-salsoline hydrochloride | 79906-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (+)-salsoline hydrochloride
• 英文别名: salsoline hydrochloride；Salsoline*HCl；(+/-)-7-methoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride；(+/-)-7-Methoxy-1-methyl-1,2,3,4-tetrahydro-isochinolin-6-ol; Hydrochlorid；Salsoliin；Salsolin；7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol Hydrochloride；7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol;hydrochloride
• CAS: 79906-89-1
• 化学式: C₁₁H₁₅NO₂*ClH
• mdl: MFCD00514065
• 分子量: 229.707
• InChiKey: PZZVNEZKNWRZEG-UHFFFAOYSA-N

物化性质

• 熔点：
  147-149 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.22
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  46.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+)-salsoline hydrochloride 在 盐酸 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 38.0h， 生成 (1S)-7-甲氧基-1-甲基-1,2,3,4-四氢异喹啉-6-醇盐酸盐
  参考文献：
  名称：

  Study of chiral β-enaminones prepared from pyrrolidine, cytisine, salsoline and 2-amino-1-(4-nitrophenyl)propane-1,3-diol: resolution of salsoline via diastereomeric modified carane-type β-enaminones

  摘要：

  A series of novel optically active beta-enaminones have been prepared regio- and stereoselectively from primary and secondary amines (pyrrolidine, cytisine salsoline and 2-amino-l-(4-nitrophenyl)propane-1,3-diol) and (+)-3-carene-derived beta-chlorovinyl ketone. Resolution of the isoquinoline alkaloid salsoline has been demonstrated as well as isolation of a single diastereomeric adduct from racemic 2-amino-1-(4-nitrophenyl)propane-1,3-diol. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00781-4

文献信息

• Babitsch, Zhurnal Prikladnoi Khimii, 1951, vol. 24, p. 74,77; engl. Ausg. S. 83, 87
  作者：Babitsch

  DOI：——

  日期：——
• Study of chiral β-enaminones prepared from pyrrolidine, cytisine, salsoline and 2-amino-1-(4-nitrophenyl)propane-1,3-diol: resolution of salsoline via diastereomeric modified carane-type β-enaminones
  作者：Sergey A. Popov、Yuri V. Gatilov、Tatjana V. Rybalova、Alexey V. Tkachev

  DOI：10.1016/s0957-4166(02)00781-4

  日期：2003.1

  A series of novel optically active beta-enaminones have been prepared regio- and stereoselectively from primary and secondary amines (pyrrolidine, cytisine salsoline and 2-amino-l-(4-nitrophenyl)propane-1,3-diol) and (+)-3-carene-derived beta-chlorovinyl ketone. Resolution of the isoquinoline alkaloid salsoline has been demonstrated as well as isolation of a single diastereomeric adduct from racemic 2-amino-1-(4-nitrophenyl)propane-1,3-diol. (C) 2003 Elsevier Science Ltd. All rights reserved.