(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)({4-[(dimethylamino)methyl]phenyl}methyl)amine | 1014247-57-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: (2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)({4-[(dimethylamino)methyl]phenyl}methyl)amine
• 英文别名: N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-1-[4-[(dimethylamino)methyl]phenyl]methanamine
• CAS: 1014247-57-4
• 化学式: C₁₉H₂₄N₂O₂
• mdl: MFCD10218475
• 分子量: 312.4
• InChiKey: CJFMAKVGBIJHEI-UHFFFAOYSA-N

物化性质

• 沸点：
  425.3±33.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.368
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Small molecule drugs and related methods for treatment of diseases related to Aβ42 oligomer formation
  申请人：ACELOT, INC.

  公开号：US10703711B2

  公开（公告）日：2020-07-07

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.

  本发明提供了用于治疗和预防与受试者体内Aβ42低聚物的形成有关的疾病的小分子药物和药物组合物。本发明进一步提供了一种减少受试者体内 Aβ42 寡聚体的形成或破坏 Aβ42 寡聚体的方法，该方法包括向有需要的受试者施用治疗有效量的药物组合物的步骤。
• SMALL MOLECULE DRUGS AND RELATED METHODS FOR TREATMENT OF DISEASES RELATED TO A 42 OLIGOMER FORMATION
  申请人：Acelot, Inc.

  公开号：EP3706727A1

  公开（公告）日：2020-09-16
• Small molecule drugs and related methods for treatment of diseases related to abeta42 oligomer formation
  申请人：ACELOT, INC.

  公开号：US20190210959A1

  公开（公告）日：2019-07-11

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
• SMALL MOLECULE DRUGS AND RELATED METHODS FOR TREATMENT OF DISEASES RELATED TO ABETA42 OLIGOMER FORMATION
  申请人：ACELOT, INC.

  公开号：US20200223788A1

  公开（公告）日：2020-07-16

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject. It further provides a method of reducing formation of or disrupting Aβ42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
• Small molecule drugs and related methods for treatment of diseases related to tdo-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation
  申请人：ACELOT,INC

  公开号：US20210052519A1

  公开（公告）日：2021-02-25

  The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of certain types of oligomers in a subject. More specifically, the drugs and compositions reduce or prevent the formation of oligomers formed from tau protein, TDP-43, Huntingtin's protein and/or alpha-synuclein. It further provides a method of reducing formation of or disrupting TDP-43, alpha-synuclein, Huntingtin's protein and/or tau protein oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.