1-[[(3R,4R)-1-cyclohexyl-4-[(2-hydroxynaphthalen-1-yl)methylideneamino]pyrrolidin-3-yl]iminomethyl]naphthalen-2-ol | 1428558-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[[(3R,4R)-1-cyclohexyl-4-[(2-hydroxynaphthalen-1-yl)methylideneamino]pyrrolidin-3-yl]iminomethyl]naphthalen-2-ol
• CAS: 1428558-84-2
• 化学式: C₃₂H₃₃N₃O₂
• 分子量: 491.633
• InChiKey: MVVPHQBMUHFTJD-LOYHVIPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  68.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (3R,4R)-N-Cyclohexyl-3,4-dihydroxy-2,5-dioxopyrrolidine 在 lithium aluminium tetrahydride 、 silica gel 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 1-[[(3R,4R)-1-cyclohexyl-4-[(2-hydroxynaphthalen-1-yl)methylideneamino]pyrrolidin-3-yl]iminomethyl]naphthalen-2-ol
  参考文献：
  名称：

  The synthesis of tetradentate salens derived from (3R,4R)-N-substituted-3,4-diaminopyrrolidines and their application in the enantioselective trimethylsilylcyanation of aromatic aldehydes

  摘要：

  The in situ formed Ti(IV) complexes of pyrrolidine-based chiral salen ligands derived from natural L-tartaric acid were evaluated as catalysts in the enantioselective trimethylsilylcyanation of aromatic aldehydes. The different activity and selectivity of the catalysts in the formation of the products were found to be dependent on the N-substituent of the pyrrolidine. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.01.015