2-phenyl-2-(tritylamino)acetonitrile | 223482-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-phenyl-2-(tritylamino)acetonitrile
• CAS: 223482-76-6
• 化学式: C₂₇H₂₂N₂
• 分子量: 374.485
• InChiKey: CBXCUVVBMAKVCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.82
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 N-benzylidene-1-phenyl-1,1-diphenylmethanamine 在 lanthanum(III) phenoxide 、 溶剂黄146 、 1,1'-联萘-2,2'-二磺酸 作用下， 以 丙腈 为溶剂， 反应 48.0h， 以42%的产率得到2-phenyl-2-(tritylamino)acetonitrile
  参考文献：
  名称：

  手性镧（III）-联萘二磺酸酯配合物催化对映选择性斯特雷克反应

  摘要：

  新型手性镧（III）-萘基二磺酸二磺酸盐配合物催化了对映选择性斯特雷克反应。促进反应的关键是半化学计量的AcOH或i- PrCO 2 H，它利用了原位生成HCN的优势。以高收率和高对映选择性获得相应的氰化产物。

  DOI：

  10.1021/ol900680f

文献信息

• An in-based 3D metal-organic framework as heterogeneous Lewis acid catalyst for multi-component Strecker reactions
  作者：Juan Chai、Ping Zhang、Jianing Xu、Hui Qi、Jing Sun、Shubo Jing、Xiaodong Chen、Yong Fan、Li Wang

  DOI：10.1016/j.ica.2018.04.037

  日期：2018.7

  A novel three-dimensional metal-organic framework (MOF) [In3(NIPH)(3) (HNIPH)(OH)(2)].4H(2)O}(n) (1) (H2NIPH = 5-nitroisophthalic acid) with one-dimensional channels was synthesized and structurally characterized. Importantly, it demonstrates excellent catalytic activity for the Strecker reactions of two or three components under mild conditions. Moreover, the catalytic recycling of 1 as a representative example was explored. It can be easily separated and reused for no less than five runs with more than 80% conversion yield in catalytic ability.
• In(III) and Sc(III) based coordination polymers derived from rigid benzimidazole-5,6-dicarboxylic acid: Synthesis, crystal structure and catalytic property
  作者：Juan Chai、Pengcheng Wang、Jia Jia、Bing Ma、Jing Sun、Yufang Tao、Ping Zhang、Li Wang、Yong Fan

  DOI：10.1016/j.poly.2017.10.028

  日期：2018.2

  Two new coordination polymers (CPs), [InCl(H(2)bidc)(2)(H2O)](n) (1) and [Sc(Hbidc)(OH)(H2O)](n) (2) (H(3)bidc = benzimidazole-5,6-dicarboxylic acid) were synthesized through a solvothermal approach. 1 exhibits a 1D infinite chain, which further constructs a 3D supramolecular framework via hydrogen bonds. 2 features a 3D supramolecular framework consisting of left- and right-handed chiral layers, which contain the left- and right-handed chiral spiral chains. The adjacent layers stack through pi-pi stacking interactions between benzene and imidazole rings. 1 exhibits excellent catalytic reactivity for the Strecker reaction and can be recycled four consecutive reactions with more than 95% conversion yields. (C) 2017 Elsevier Ltd. All rights reserved.