5,5-Dimethyl-10-[5-(piperidino)valeryloxy]-8(3-methyl-2-octyl)-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d] pyridine hydrochloride | 49637-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5,5-Dimethyl-10-[5-(piperidino)valeryloxy]-8(3-methyl-2-octyl)-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d] pyridine hydrochloride
• 英文别名: 5,5-Dimethyl-10-[5-(piperidino)valeryloxy]-8-(3-methyl-2-octyl)-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d] pyridine hydrochloride；[5,5-dimethyl-8-(3-methyloctan-2-yl)-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-yl] 5-piperidin-1-ylpentanoate;hydrochloride
• CAS: 49637-11-8
• 化学式: C₃₆H₅₄N₂O₃*ClH
• 分子量: 599.297
• InChiKey: GABUTTIOJWGUNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.25
• 重原子数：
  42
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  SP 1 、 5-(哌啶-1-基)戊酸盐酸 、 N,N'-二环己基碳二亚胺 、 二氯甲烷 、 在 N,N-二环己脲 、 methylene chloride diethyl ether 作用下， 以 cyclohexane, methylene chloride 、 chloroform methanol 为溶剂， 反应 23.0h， 以gave 2.5 g的产率得到5,5-Dimethyl-10-[5-(piperidino)valeryloxy]-8(3-methyl-2-octyl)-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d] pyridine hydrochloride
  参考文献：
  名称：

  Novel heterocyclic esters of benzopyranopyridines

  摘要：

  这是一种新型杂环酯化合物，其化学式为##STR1##其中，R.sub.1为氢、低碳基、低脂肪酰基、环烷基-低碳基、环烷基-低脂肪酰基、低烯基、低炔基、卤代低烯基、苯基-低碳基、苯基-低烯基或苯基-低炔基；R.sub.2为低碳基；R.sub.3为一种具有1到20个碳原子的烷基或环烷基-低碳基；Y为一种具有1到8个碳原子的直链或支链烷基；R.sub.4为##STR2##其中，a为1到4的整数，b为1到4的整数，X为CH.sub.2、O、S或N--R.sub.5，R.sub.5为氢或低碳基；需要注意的是，当X为O、S或N--R.sub.5时，a和b必须分别为2，且R.sub.6为与环中碳原子相连的氢或低碳基；此外，还包括其酸加成盐。

  公开号：

  US04042694A1

文献信息

• Novel heterocyclic esters of benzopyranopyridines
  申请人：Sharps Associates

  公开号：US04042694A1

  公开（公告）日：1977-08-16

  Novel heterocyclic esters of benzopyranopyridines represented by the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkanoyl, cycloalkyl-lower alkyl, cycloalkyl-lower alkanoyl, lower alkenyl, lower alkynyl, halo-loweralkenyl, phenyl-lower alkyl, phenyl-lower alkenyl or phenyl-lower alkynyl; R.sub.2 is lower alkyl; R.sub.3 is an alkyl having one to twenty carbon atoms or a cycloalkyl-lower alkyl, Y is a straight or branched chain alkylene having one to eight carbon atoms, and R.sub.4 is a group of the formula ##STR2## a is an integer from 1 to 4, b is an integer from 1 to 4 and X is CH.sub.2, O, S or N--R.sub.5 with R.sub.5 being hydrogen or lower alkyl, with the limitation that when X is O, S or N--R.sub.5, a and b each must be 2 and R.sub.6 is hydrogen or a lower alkyl group bonded to a carbon in the ring; and the acid addition salts thereof.

  这是一种新型杂环酯化合物，其化学式为##STR1##其中，R.sub.1为氢、低碳基、低脂肪酰基、环烷基-低碳基、环烷基-低脂肪酰基、低烯基、低炔基、卤代低烯基、苯基-低碳基、苯基-低烯基或苯基-低炔基；R.sub.2为低碳基；R.sub.3为一种具有1到20个碳原子的烷基或环烷基-低碳基；Y为一种具有1到8个碳原子的直链或支链烷基；R.sub.4为##STR2##其中，a为1到4的整数，b为1到4的整数，X为CH.sub.2、O、S或N--R.sub.5，R.sub.5为氢或低碳基；需要注意的是，当X为O、S或N--R.sub.5时，a和b必须分别为2，且R.sub.6为与环中碳原子相连的氢或低碳基；此外，还包括其酸加成盐。
• US4025630A
  申请人：——

  公开号：US4025630A

  公开（公告）日：1977-05-24
• US4042694A
  申请人：——

  公开号：US4042694A

  公开（公告）日：1977-08-16
• Anesthesia methods using benzopyrans and esters thereof as
  申请人：Abbott Laboratories

  公开号：US04025630A1

  公开（公告）日：1977-05-24

  Improved anesthesia methods comprising pretreating a patient to be anesthetized with a benzopyran of formula I ##STR1## wherein, in the C ring, X is NR.sub.1, S, CH.sub.2 or ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkanoyl, cycloalkyloweralkyl, cycloalkylloweralkanoyl, cycloalkyl, haloloweralkyl, haloloweralkenyl, phenylloweralkyl, phenyloweralkenyl or phenyloweralkylnyl; m is an integer from 0 to 3, n is an integer from 0 to 3 and n + m = 2 or 3; or the C ring is quinuclidine ring ##STR3## R.sub.2 is loweralkyl; R.sub.3 is hydrogen or ##STR4## wherein Y is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.6, R.sub.6 being hydrogen or loweralkyl, with the limitation that when Z is O, S or NR.sub.5, the sum of a and b is 3 or 4, and R.sub.5 is hydrogen or loweralkyl; R.sub.4 is C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or ##STR5## wherein Y is a straight or branched chain alkylene group having from one to ten carbon atoms, and each R.sub.7, R.sub.8 and R.sub.9 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof, with the limitation that when X is ##STR6## m = 2 and n = 2, R.sub.3 cannot be hydrogen.

  改进的麻醉方法包括使用式I的苯并吡喃预处理待麻醉的患者，其中在C环中，X为NR.sub.1，S，CH.sub.2或##STR2##，R.sub.1为氢，低烷基，低烯基，低炔基，低酰基，环烷基低烷基，环烷基低酰基，环烷基，卤代低烷基，卤代低烯基，苯基低烷基，苯基低烯基或苯基低烷基基；m为0至3的整数，n为0至3的整数，n + m = 2或3；或C环为喹啉环##STR3##，R.sub.2为低烷基；R.sub.3为氢或##STR4##，其中Y为直链或支链烷基链，具有1至8个碳原子，a为1至4的整数，b为1至4的整数，Z为CH.sub.2，O，S或NR.sub.6，其中R.sub.6为氢或低烷基，限制条件为当Z为O，S或NR.sub.5时，a和b的和为3或4，R.sub.5为氢或低烷基；R.sub.4为C.sub.1-C.sub.20直链或支链烷基，环烷基，或##STR5##，其中Y为具有1至10个碳原子的直链或支链烷基链，每个R.sub.7，R.sub.8和R.sub.9是相同或不同的羟基，卤素，三氟甲基或低烷基成员的群；及其药学上可接受的盐，限制条件为当X为##STR6##时，m = 2且n = 2时，R.sub.3不能为氢。