3-[1-(2,2-dimethylpropanoyl)-3-[methyl(pyridin-2-yl)carbamoyl]-7-(propan-2-yl)indolizin-2-yl]-2,2-dimethylpropanoic acid | 1215281-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 3-[1-(2,2-dimethylpropanoyl)-3-[methyl(pyridin-2-yl)carbamoyl]-7-(propan-2-yl)indolizin-2-yl]-2,2-dimethylpropanoic acid
• 英文别名: 3-[1-(2,2-Dimethylpropanoyl)-3-[methyl(pyridin-2-yl)carbamoyl]-7-propan-2-ylindolizin-2-yl]-2,2-dimethylpropanoic acid
• CAS: 1215281-49-4
• 化学式: C₂₈H₃₅N₃O₄
• 分子量: 477.604
• InChiKey: BEWXJSXDBIYJHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• INDOLIZINE INHIBITORS OF LEUKOTRIENE PRODUCTION
  申请人：Bosanac Todd

  公开号：US20110275627A1

  公开（公告）日：2011-11-10

  The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein X 1 to X 4 , R 1 to R 4 , A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  本发明涉及式(I)的化合物及其药用可接受盐，其中X1至X4，R1至R4，A，B，D和m的定义如本文所述。该发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物的方法以及在这些过程中有用的中间体。
• US8618300B2
  申请人：——

  公开号：US8618300B2

  公开（公告）日：2013-12-31
• [EN] INDOLIZINE INHIBITORS OF LEUKOTRIENE PRODUCTION<br/>[FR] INHIBITEURS INDOLIZINE DE LA PRODUCTION DE LEUKOTRIÈNES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010027762A1

  公开（公告）日：2010-03-11

  The present invention relates to compounds of formula I and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.