4-((1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-(4-morpholin-4-ylphenyl)prop-1-enyl)phenol | 476489-05-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-((1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-(4-morpholin-4-ylphenyl)prop-1-enyl)phenol
• 英文别名: 4-((l E)-1 - {4-[2-(dimethylamino)ethoxy]phenyl}-2-(4-morpholin-4-ylphenyl)prop-1-enyl)phenol；4-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-morpholin-4-ylphenyl)prop-1-enyl]phenol
• CAS: 476489-05-1
• 化学式: C₂₉H₃₄N₂O₃
• 分子量: 458.601
• InChiKey: AISZPIHUEFGZHZ-QUPMIFSKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions
  申请人：——

  公开号：US20030143559A1

  公开（公告）日：2003-07-31

  Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective “molecular gene switches” is disclosed. Methods of regulating gene function using these switches are provided.

  提供了类固醇受体配体结合域（LBD）的突变体和具有特异性结合亲和力的合成配体。揭示了利用这些LBD-配体组合构建选择性“分子基因开关”的用途。提供了利用这些开关调节基因功能的方法。
• NOVEL ESTROGEN RECEPTOR LIGAND BINDING DOMAIN VARIANTS AND NOVEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS
  申请人：Novartis AG

  公开号：EP1397382B1

  公开（公告）日：2008-08-06
• EP1397382A4
  申请人：——

  公开号：EP1397382A4

  公开（公告）日：2005-08-24
• US7381813B2
  申请人：——

  公开号：US7381813B2

  公开（公告）日：2008-06-03
• [EN] NOVEL ESTROGEN RECEPTOR LIGAND BINDING DOMAIN VARIANTS AND NOVEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] NOUVEAUX VARIANTS DU DOMAINE DE LIAISON AUX LIGANDS DU RECEPTEUR OESTROGENIQUE ET NOUVEAUX LIGANDS ET COMPOSITIONS PHARMACEUTIQUES
  申请人：NOVARTIS AG

  公开号：WO2002097050A2

  公开（公告）日：2002-12-05

  Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective 'molecular gene switches' is disclosed. Methods of regulating gene function using these switches are provided.