2-Hydroxy-1-(4-chlorophenyl)-2,2-diphenylethanone | 63704-18-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-Hydroxy-1-(4-chlorophenyl)-2,2-diphenylethanone
• 英文别名: 1-(4-Chlorophenyl)-2-hydroxy-2,2-diphenylethanone
• CAS: 63704-18-7
• 化学式: C₂₀H₁₅ClO₂
• 分子量: 322.791
• InChiKey: LCXWKSURQMPJBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  α,α-diphenylchloroacetophenone 生成 2-Hydroxy-1-(4-chlorophenyl)-2,2-diphenylethanone
  参考文献：
  名称：

  Oxidative cleavage of .alpha.-ketols and related ketones with alkaline hydrogen peroxide

  摘要：

  DOI：

  10.1021/jo00445a016

文献信息

• Intramolecular and intermolecular ketone–ester reductive coupling reactions promoted by samarium(II) iodide
  作者：Yunkui Liu、Yongmin Zhang

  DOI：10.1016/s0040-4039(01)01107-8

  日期：2001.8

  Intramolecular and intermolecular ketone–ester reductive coupling reactions promoted by SmI2 have been studied. Substituted 2-hydroxy-5-ethoxycarbonylcyclopentanones, 5-ethoxycarbonylcyclopentenones and α-ketols were prepared in moderate to good yields at room temperature or under reflux under neutral conditions.

  已经研究了由SmI 2促进的分子内和分子间酮-酯还原偶联反应。在室温下或在中性条件下在回流下以中等至良好的产率制备2-羟基-5-乙氧基羰基环戊烯酮，5-乙氧基羰基环戊烯酮和α-酮醇。
• Samarium(II) iodide promoted novel reductive coupling reactions of ketones and nitriles
  作者：Longhu Zhou、Yongmin Zhang、Daqing Shi

  DOI：10.1016/s0040-4039(98)01984-4

  日期：1998.11

  The intramolecular and intermolecular reductive coupling reaction of ketones-nitriles promoted by SmI2 were studied.

  研究了SmI 2促进的酮腈的分子内和分子间还原偶联反应。
• Samarium(II) Iodide-Promoted Intermolecular and Intramolecular Ketone-Nitrile Reductive Coupling Reactions
  作者：Longhu Zhou、Yongmin Zhang、Daqing Shi

  DOI：10.1055/s-2000-6220

  日期：——

  Samarium(II) iodide, a strong one-electron transfer reducing reagent, has been successfully utilized for the intermolecular and intramolecular reductive coupling reactions of ketones with nitriles. α-Hydroxy ketones, monocyclic, fused bicyclic α-hydroxy ketones and monocyclic α-amino alcohols composed of a number of substitution patterns have been prepared in good yields at room temperature or reflux under neutral conditions. The procedure can avoid overreduction of the resulting of α-hydroxy ketones or α-amino alcohols. The crystal structures of monocyclic α-amino alcohols are reported.

  钐（II）碘化物是一种强的一电子转移还原试剂，已成功用于酮类与腈类的分子间和分子内还原偶联反应。在室温或回流的中性条件下，已经制备了多种取代模式的α-羟基酮、单环和融合双环的α-羟基酮以及单环的α-氨基醇，产率良好。该方法能够避免生成的α-羟基酮或α-氨基醇的过度还原。还报告了单环α-氨基醇的晶体结构。
• US6989052B1
  申请人：——

  公开号：US6989052B1

  公开（公告）日：2006-01-24
• Oxidative cleavage of .alpha.-ketols and related ketones with alkaline hydrogen peroxide
  作者：Yoshiro Ogata、Yasuhiko Sawaki、Masami Shiroyama

  DOI：10.1021/jo00445a016

  日期：1977.12