1-(3,4,5-trimethoxyphenyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline | 63979-53-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-(3,4,5-trimethoxyphenyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 6-methyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline；6-Methyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isochinolin；2-Methyl-6,7-methylenedioxy-1,2,3,4-tetrahydro-1-(3,4,5-trimethoxyphenyl)isoquinoline；6-methyl-5-(3,4,5-trimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline
• CAS: 63979-53-3
• 化学式: C₂₀H₂₃NO₅
• 分子量: 357.406
• InChiKey: YNNAIAGUISNRCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 聚合甲醛 作用下， 生成 1-(3,4,5-trimethoxyphenyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Synthesis of Some Isoquinoline Derivatives Related to Podophyllotoxin

  摘要：

  DOI：

  10.1021/ja01167a114

文献信息

• Nucleophilic Addition of Lewis Acid Complexed α-Amino Carbanions to Arynes: Synthesis of 1-Aryl-N-methyl-1,2,3,4-tetrahydroisoquinolines
  作者：Kamal Singh、Paramjit Singh、Esha Sharma、Yadwinder Deol

  DOI：10.1055/s-0033-1341239

  日期：——

  The direct C-1 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines via coupling of alpha-amino carbanions derived from Lewis acid complexed tetrahydroisoquinolines and in situ generated arynes is described. This process provides an easy access to the title compounds and a new synthetic route to (+/-)-cryptostyline alkaloids.
• Synthesis of Some Isoquinoline Derivatives Related to Podophyllotoxin
  作者：Wilkins Reeve、William M. Eareckson

  DOI：10.1021/ja01167a114

  日期：1950.11