| 1264294-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1264294-64-5
• 化学式: C₃₅H₄₁N₃O₇
• 分子量: 615.726
• InChiKey: LFOCSRIPYSBGFH-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 、 水 作用下， 反应 0.03h， 生成 2-(aminooxymethyl)-8-(2-phenylethenyl)-1H-pyrrolo[2,3-f]isoquinoline-3-carboxylic acid
  参考文献：
  名称：

  In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I

  摘要：

  Pyrrolo[2,3-f]isoquinoline based amino acids, tetracyclic lactams and cyclic ketone analogues are described as novel MK2 inhibitors with IC(50) as low as 5 nM and good selectivity profiles against a number of related kinases including ERK, p38 alpha and JNKs. TNF alpha release was suppressed from human peripheral blood mononuclear cells (hPBMCs), and a representative compound inhibited LPS induced TNF alpha release in mice illustrating the potential of this series to provide orally active MK2 inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.024