4-[1-(4-羧基苯基)-3-氧代-2-苯并呋喃-1-基]苯甲酸 | 7535-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 4-[1-(4-羧基苯基)-3-氧代-2-苯并呋喃-1-基]苯甲酸
• 英文名称: 3,3-diphenylphthalide-4,4'-dicarboxylic acid
• 英文别名: 4',4''-Diphenylphthalidendicarbonsaeure；3,3-bis-(4-carboxy-phenyl)-phthalide；3,3-Bis-(4-carboxy-phenyl)-phthalid；4,4'-(3-Oxo-1,3-dihydroisobenzofuran-1,1-diyl)dibenzoic acid；4-[1-(4-carboxyphenyl)-3-oxo-2-benzofuran-1-yl]benzoic acid
• CAS: 7535-16-2
• 化学式: C₂₂H₁₄O₆
• 分子量: 374.35
• InChiKey: CEPYVIYDCXDLEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[1-(4-羧基苯基)-3-氧代-2-苯并呋喃-1-基]苯甲酸 在 三氯化铝 、 氯化亚砜 作用下， 反应 16.0h， 生成 3,3-bis[4-(4-fluorobenzoyl)phenyl]phthalide
  参考文献：
  名称：

  Synthesis of phthalide-containing dihalogeno derivatives and polyarylene ether ketones based on them

  摘要：

  New activated phthalide-containing dihalogeno derivatives were synthesized, and cardo polyarylene ether ketones based on them were prepared. The effect of the type of the halogen atom (fluorine, chlorine, or bromine) on the efficiency of polycondensation was estimated. It was demonstrated that high-molecular-weight cardo polyarylene ether ketones can be obtained only from the difluoro derivative. The synthesized polymers are amorphous compounds characterized by high glass transition temperatures (210-250 degrees C). These polymers are soluble in many organic solvents and form strong transparent films.

  DOI：

  10.1007/bf02494901
• 作为产物：
  描述：

  2-(4-甲基苯甲酰)苯甲酸 在 potassium permanganate 、 三氯化铝 、 potassium carbonate 、 锌 作用下， 生成 4-[1-(4-羧基苯基)-3-氧代-2-苯并呋喃-1-基]苯甲酸
  参考文献：
  名称：

  Limpricht, Justus Liebigs Annalen der Chemie, 1898, vol. 299, p. 310

  摘要：

  DOI：

文献信息

• Small molecule toll-like receptor (TLR) antagonists
  申请人：Lipford B. Grayson

  公开号：US20070232622A1

  公开（公告）日：2007-10-04

  The invention provides methods and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a small molecule having a core structure including at least two rings. Certain of the compounds are 4-primary amino quinolines. Many of the compounds and methods are useful specifically for inhibiting immune stimulation involving at least one of TLR9, TLR8, TLR7, and TLR3. The methods may have use in the treatment of autoimmunity, inflammation, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.

  本发明提供了用于调节通过Toll样受体信号传导的方法和组合物。该方法涉及使用一个包含至少两个环的核心结构的小分子接触TLR表达的细胞。其中某些化合物是4-主氨基喹啉。许多化合物和方法特别适用于抑制至少一个TLR9、TLR8、TLR7和TLR3的免疫刺激。该方法可能在治疗自身免疫、炎症、过敏、哮喘、移植排斥、移植物抗宿主病、感染、败血症、癌症和免疫缺陷方面有用。
• RESIN MATERIAL FOR GAS SEPARATION BASE AND PROCESS FOR PRODUCING THE SAME
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1213049A1

  公开（公告）日：2002-06-12

  This invention relates to resin material for gas separation base containing a cardo polyimide structure in which the hydrogen atoms in the side-chain benzyl and/or allyl position are halogenated at a rate of modification by halogen of 0.1% or more or resin material for gas separation base containing polymer in which the hydrogen atoms in the side-chain benzyl and/or allyl position are halogenated at a rate of modification by halogen of 34% or more and, additionally, relates to polymer which serves as raw material for the aforementioned resin material for gas separation base containing a cardo polymer structure and a process for producing said polymer; said polymer not only excels in such properties as solvent solubility, ease of conversion to film by a wet process, thermal stability, and chemical stability but also performs well in gas permeability and the process of this invention makes it possible to produce gas separation base, particularly gas separation membrane, whose gas permeability and gas selectivity can be readily controlled.

  本发明涉及用于气体分离基础的树脂材料，该材料含有一种卡多聚酰亚胺结构，其中侧链苄基和/或烯丙基位置上的氢原子被卤化，卤化率为 0.1%或更高，或含有侧链苄基和/或烯丙基位置的氢原子被卤化的比率为 34% 或更高的聚合物的气体分离基树脂材料，此外，还涉及作为上述含有卡道聚合物结构的气体分离基树脂材料原料的聚合物以及生产上述聚合物的工艺；所述聚合物不仅在溶剂溶解性、通过湿法工艺转化为薄膜的难易程度、热稳定性和化学稳定性等性能方面表现出色，而且在气体渗透性方面也有很好的表现，本发明的工艺可以生产出气体渗透性和气体选择性易于控制的气体分离基料，特别是气体分离膜。
• POLYMER ANISOTROPIC ELECTROCONDUCTIVE GLUING MATERIAL AND A GLUING METHOD
  申请人：Koltsova, Anastasia Adrianovna

  公开号：EP2014735A2

  公开（公告）日：2009-01-14

  The invention relates to the semiconductor device making technology, namely, to methods and compositions for the technology for manufacturing semiconductor devices and integrated microcircuits, particularly to the technology for creating new adhesive electroconductive compositions. The task of the claimed invention is in providing a polymer anisotropic electroconductive composite adhesive material ensuring increased reliability of positive characteristic replication, high electroconductivity and high anisotropy in the direction perpendicular to the adhesion plane, as well as a method of adhering. The set task is solved by creating a polymer anisotropic electroconductive composite adhesive material based on dielectrics, among which the necessary component ensuring high anisotropy are agents having unstable electron molecular state, which electroconductivity depends on action of external physical fields, and which are characterized by high polarizability and/or bistable electron energy structure with regard to the process of excess electron capture. Other components carry out important, but ancillary functions (e.g., increasing of strength, adhesion, workability, etc.). Novelty is in that such a polymer composite material is created based only on dielectrics, among which must be necessary components having features represented above.

  本发明涉及半导体器件制造技术，即涉及半导体器件和集成微电路制造技术的方法和组合物，特别是涉及制造新型粘合导电组合物的技术。 本发明的任务是提供一种聚合物各向异性导电复合粘合材料，确保提高正特性复制的可靠性、高导电性和垂直于粘合平面方向的高各向异性，以及一种粘合方法。 要解决上述问题，就必须在电介质的基础上制造一种聚合物各向异性导电复合粘合材料，其中确保高各向异性的必要成分是具有不稳定电子分子状态的介质，这种介质的导电性取决于外部物理场的作用，其特点是在过量电子捕获过程中具有高极化性和/或双稳态电子能量结构。其他成分具有重要的辅助功能（如增加强度、粘附性、可加工性等）。新颖之处在于，这种聚合物复合材料仅以电介质为基础，其中必须包含具有上述特征的必要成分。
• Molekulare Resonanzsysteme V. Einige neue Phtaleine
  作者：G. Schwarzenbach、M. Brandenberger

  DOI：10.1002/hlca.193702001170

  日期：——
• SALAZKIN S. N.; BERIDZE L. A.; KOMAROVA L. I.; PAVLOVA T. S.; KORSHAK V. +, IN-T EHLEMENTOORGAN. SOEDIN. AN CCCP. M., 1975, 23S., ILL. BIBLIOGR. 13 N+
  作者：SALAZKIN S. N.、 BERIDZE L. A.、 KOMAROVA L. I.、 PAVLOVA T. S.、 KORSHAK V. +

  DOI：——

  日期：——