1,2-Naphthalenedicarboxylic acid, 1-mono(phenylmethyl)ester | 93288-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,2-Naphthalenedicarboxylic acid, 1-mono(phenylmethyl)ester
• 英文别名: 1-Phenylmethoxycarbonylnaphthalene-2-carboxylic acid
• CAS: 93288-13-2
• 化学式: C₁₉H₁₄O₄
• 分子量: 306.318
• InChiKey: CDSHBZSGVHCDHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS
  申请人：Sugen, Inc.

  公开号：EP1212296A1

  公开（公告）日：2002-06-12
• [EN] PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS<br/>[FR] MIMETIQUES PHOSPHATES ET PROCEDES DE TRAITEMENT UTILISANT DES INHIBITEURS DE PHOSPHATASE
  申请人：SUGEN INC

  公开号：WO2001016097A1

  公开（公告）日：2001-03-08

  The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.